SCHEMBL8480942

SCHEMBL8480942

NNc1nc(Cl)nc2[nH]cnc12

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
XDH P47989 1/20 0.41
KDM4E B2RXH2 1/20 0.32
CSNK2A1 P68400 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.31
TMIGD3 P0DMS9 1/20 0.31
HTR2C P28335 1/20 0.31
HTR2B P41595 1/20 0.31
PLK4 O00444 1/20 0.31
PAK4 O96013 1/20 0.31
YTHDC1 Q96MU7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30677300 1.00 XDH (0.41) XDHKDM4ECSNK2A1SMN1; SMN2TMIGD3
SCHEMBL130696 0.81 XDH (0.57) XDHYTHDC1
SCHEMBL30115173 0.81 CDK1 (0.41) XDHKDM4ECSNK2A1SMN1; SMN2
SCHEMBL29745 0.81 CDK1 (0.41) XDHKDM4ECSNK2A1SMN1; SMN2
Hydrochloric Acid SCHEMBL28873719 0.79 CDK1 (0.40) XDHKDM4ECSNK2A1SMN1; SMN2
SCHEMBL1358951 0.79 CDK1 (0.40) XDHKDM4ECSNK2A1SMN1; SMN2
SCHEMBL7521321 0.79 CDK1 (0.40) XDHKDM4ECSNK2A1SMN1; SMN2
SCHEMBL8485064 0.79 PDPK1 (0.36)
SCHEMBL14224143 0.78 XDH (0.40) XDHCSNK2A1
SCHEMBL14196060 0.78 XDH (0.36) XDHSMN1; SMN2TMIGD3HTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250388582-A1 NOVEL BICYCLIC HETEROARYL COMPOUND AND USE THEREOF ILDONG PHARMACEUTICAL CO LTD (KR) 2025-12-25 US disclosed
EP-4556476-A1 NOVEL BICYCLIC HETEROARYL COMPOUND AND USE THEREOF Ildong Pharmaceutical Co., Ltd. (KR) 2025-05-21 EP disclosed
US-7399754-B2 N2-quinoline or isoquinoline substituted purine derivatives ZHEJIANG MEDICINE CO., LTD. (CN) 2008-07-15 US disclosed
US-5990118-A NOVEL PURINE COMPOUNDS AND TRIAZOLOPURINE COMPOUNDS WHICH INHIBIT XANTHINE OXIDASE; REMEDIES FOR HYPERURICEMIA, AND AS PREVENTIVE AND THERAPEUTIC AGENTS FOR GOUT YAMASA CORPORATION (JP) 1999-11-23 US disclosed
EP-0811624-A1 PURINE COMPOUNDS AND XANTHINE OXIDASE INHIBITORS YAMASA CORPORATION (JP) 1997-12-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250388582-A1 NOVEL BICYCLIC HETEROARYL COMPOUND AND USE THEREOF GBA1, PIKFYVE, MAN2B1 XDH 2221/4885KDM4E 2168/4885CSNK2A1 127/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.