SCHEMBL130696

SCHEMBL130696

CNc1nc(Cl)nc2[nH]cnc12

nearest known ligand 0.57

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
XDH P47989 1/20 0.57
YTHDC1 Q96MU7 12/20 0.47
YTHDF3 Q7Z739 2/20 0.37
YTHDF1 Q9BYJ9 2/20 0.37
YTHDF2 Q9Y5A9 2/20 0.37
PDE2A O00408 1/20 0.37
ADORA3 P0DMS8 1/20 0.35
ADORA2A P29274 1/20 0.35
ADORA1 P30542 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8480942 0.81 XDH (0.41) XDHYTHDC1
SCHEMBL30677300 0.81 XDH (0.41) XDHYTHDC1
SCHEMBL7110908 0.81 XDH (0.41) XDHADORA3ADORA1
SCHEMBL12186854 0.81 XDH (0.41) XDHADORA3ADORA1
SCHEMBL16366673 0.80 XDH (0.41) XDHYTHDC1ADORA3ADORA1
SCHEMBL11876693 0.79 XDH (0.39) XDHYTHDC1YTHDF2
SCHEMBL4430662 0.79 XDH (0.39) XDHYTHDC1YTHDF2
SCHEMBL12187031 0.78 XDH (0.40) XDHADORA3ADORA1
SCHEMBL14196063 0.78 XDH (0.40) XDH
SCHEMBL19261289 0.78 XDH (0.40) XDHADORA3ADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2516637-B1 THERMOSTABLE BIOCATALYST COMBINATION FOR NUCLEOSIDE SYNTHESIS PLASMIA BIOTECH S L (ES) 2016-04-20 EP claimed
CN-104447746-A Compound for activating AMPK and application thereof HUAAN MEDICAL CO LTD 2015-03-25 CN claimed
US-20140303112-A1 Method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK) ENERGENESIS BIOMEDICAL CO., LTD (TW) 2014-10-09 US claimed
EP-2516637-A1 THERMOSTABLE BIOCATALYST COMBINATION FOR NUCLEOSIDE SYNTHESIS Plasmia Biotech, S.L. (ES) 2012-10-31 EP claimed
US-20120264175-A1 THERMOSTABLE BIOCATALYST COMBINATION FOR NUCLEOSIDE SYNTHESIS BRILL ENGINES, S.L. (ES) 2012-10-18 US claimed
WO-2011076894-A1 THERMOSTABLE BIOCATALYST COMBINATION FOR NUCLEOSIDE SYNTHESIS INSTITUT UNIV. DE CIÈNCIA I TECNOLOGIA, S.A. (ES) 2011-06-30 WO claimed
EP-2338985-A1 Thermostable biocatalyst combination for nucleoside synthesis Institut Univ. de Ciència i Tecnologia, s.a. (ES) 2011-06-29 EP claimed
US-20080089957-A1 Monocotyledon plant indications extract compositions, method of preparation and pharmaceutical compositions containing them ACADEMIA SINICA (TW) 2008-04-17 US claimed
EP-3778604-B1 LRRK2 INHIBITORS AND METHODS OF MAKING AND USING THE SAME DANA FARBER CANCER INST INC (US) 2026-01-07 EP disclosed
US-12421273-B2 Ectonucleotidase inhibitors and methods of use thereof ANTENGENE THERAPEUTICS LIMITED (CN) 2025-09-23 US disclosed
US-20240174647-A1 KINASE MODULATORS AND METHODS OF USE THEREOF NEURON23, INC. 2024-05-30 US disclosed
WO-2024105159-A1 LIGANDS OF THE M6A-RNA READERS UNIVERSITY OF ZURICH (CH) 2024-05-23 WO disclosed
US-20240132533-A1 ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE THEREOF ANTENGENT THERAPEUTICS LIMITED (CN) 2024-04-25 US disclosed
CN-112888696-B Exonuclease inhibitors and methods of use thereof 德琪医疗有限公司 2024-04-16 CN disclosed
WO-2008017161-A1 AZACYCLOALKANE DERIVATIVES AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE MERCK FROSST CANADA LTD. (CA) 2008-02-14 WO disclosed
US-5663154-A VIRICIDES, HIV, HEPATITIS GLAXO WELLCOME INC. (US) 1997-09-02 US disclosed
EP-0625158-A1 THERAPEUTIC NUCLEOSIDES THE WELLCOME FOUNDATION LIMITED (GB) 1994-11-23 EP disclosed
WO-1993014103-A1 THERAPEUTIC NUCLEOSIDES THE WELLCOME FOUNDATION LIMITED (GB) 1993-07-22 WO disclosed
US-5110818-A Antiepileptic agents CIBA-GEIGY CORPORATION (US) 1992-05-05 US disclosed
EP-0363320-A2 Substituted 9H purine CIBA-GEIGY AG (CH) 1990-04-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240132533-A1 ECTONUCLEOTIDASE INHIBITORS AND METHODS OF USE THEREOF NT5E, ENTPD5, NT5C2 XDH 337/4885YTHDC1 3612/4885YTHDF3 2812/4885
US-20140303112-A1 Method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK) PRKAG2, PRKAB2, PRKAG1 XDH 253/4885YTHDC1 4697/4885YTHDF3 4649/4885
US-12421273-B2 Ectonucleotidase inhibitors and methods of use thereof NT5E, ENTPD5, NT5C2 XDH 337/4885YTHDC1 3612/4885YTHDF3 2812/4885
US-20080089957-A1 Monocotyledon plant indications extract compositions, method of preparation and pharmaceutical compositions containing them OAT, TPMT, NUDT1 XDH 5/4885YTHDC1 783/4885YTHDF3 619/4885
US-20240174647-A1 KINASE MODULATORS AND METHODS OF USE THEREOF LRRK2, MAP3K20, MAP3K5 XDH 2699/4885YTHDC1 3450/4885YTHDF3 3004/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.