Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 9/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | MC3R | P41968 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8486538 | 0.84 | PTGDR2 (0.36) | LTB4R2PKMPTGDR2AGTR1HDAC3 | |
| SCHEMBL8911110 | 0.83 | LTB4R2 (0.34) | LTB4R2PKMAGTR1TSHR | |
| SCHEMBL8482791 | 0.80 | HRH3 (0.34) | AGTR1ALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL8482788 | 0.79 | PTPN1 (0.34) | ALDH1A1GRM2 | |
| SCHEMBL8487085 | 0.78 | LTB4R2 (0.36) | LTB4R2PKMPTGDR2AGTR1HDAC3 | |
| SCHEMBL8808766 | 0.76 | LTB4R2 (0.35) | LTB4R2PKMPTGDR2AGTR1HDAC3 | |
| SCHEMBL8486942 | 0.75 | LTB4R2 (0.35) | LTB4R2PKMAGTR1ALDH1A1LMNA | |
| SCHEMBL2515 | 0.75 | LTB4R2 (0.49) | LTB4R2AGTR1 | |
| SCHEMBL8485848 | 0.74 | LTB4R2 (0.41) | LTB4R2PTGDR2AGTR1 | |
| SCHEMBL8486521 | 0.73 | AGTR1 (0.40) | LTB4R2PKMPTGDR2AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955487-A | TREATING HIGH BLOOD PRESSURE, CARDIAC INSUFFICIENCY, GLAUCOMA | CIBA-GEIGY CORPORATION (US) | 1999-09-21 | — | — | US | disclosed |
| US-5620998-A | CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |
| US-5506240-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |