Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8477271 | 0.99 | KDM4E (0.47) | KDM4EALDH1A1ALOX5MCHR1CYP26A1 | |
| SCHEMBL8790835 | 0.89 | EGFR (0.51) | ALOX5MCHR1EGFRLTA4H | |
| Hydrochloric Acid SCHEMBL8477293 | 0.88 | EGFR (0.52) | ALOX5MCHR1EGFRLTA4H | |
| SCHEMBL8477015 | 0.85 | ALOX5 (0.51) | KDM4EALDH1A1ALOX5CYP26A1CYP3A4 | |
| SCHEMBL10449012 | 0.83 | KDM4E (0.48) | KDM4EALDH1A1ALOX5MCHR1CYP26A1 | |
| Hydrochloric Acid SCHEMBL8477484 | 0.83 | AOC3 (0.54) | KDM4EALDH1A1CYP3A4SLC6A4 | |
| SCHEMBL8581500 | 0.83 | MAOB (0.48) | ALOX5MCHR1 | |
| Hydrochloric Acid SCHEMBL8482429 | 0.82 | KDM4E (0.47) | KDM4EALDH1A1ALOX5MCHR1CYP26A1 | |
| SCHEMBL9127543 | 0.76 | ALOX5 (0.63) | ALOX5CYP26A1CYP3A4 | |
| SCHEMBL8483186 | 0.76 | ALOX5 (0.52) | KDM4EALDH1A1ALOX5MCHR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5872117-A | TREATING CEREBROVASCULAR DEMENTIA, SENILE DEMENTIA, ALZHEIMER'S DEMENTIA, SEQUELAE OF ISCHEMIC ENCEPHALOPATHY AND CEREBRAL APOPLEXY | TOYAMA CHEMICAL CO., LTD. (JP) | 1999-02-16 | — | — | US | disclosed |
| US-5719150-A | ALZHEIMER'S DISEASE | TOYAMA CHEMICAL CO., LTD. (JP) | 1998-02-17 | — | — | US | disclosed |
| US-5658904-A | COGNITION ACTIVATORS; BRAIN DISORDERS; ALZHEIMER*S DISEASE | TOYAMA CHEMICAL CO., LTD. (JP) | 1997-08-19 | — | — | US | disclosed |
| US-5612381-A | 1,2-ethanediol derivative and salt thereof process for producing the same, and cerebral function-improving agent comprising the same | TOYAMA CHEMICAL CO., LTD. (JP) | 1997-03-18 | — | — | US | disclosed |
| EP-0589484-B1 | 1,2-Ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same | TOYAMA CHEMICAL CO LTD (JP) | 1996-10-16 | — | — | EP | disclosed |
| US-5472984-A | 1,2-ethanediol derivative and salt thereof and cerebral function-improving agent comprising the same | TOYAMA CHEMICAL CO., LTD. (JP) | 1995-12-05 | — | — | US | disclosed |
| EP-0589484-A1 | 1,2-Ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same | TOYAMA CHEMICAL CO., LTD. (JP) | 1994-03-30 | — | — | EP | disclosed |
| EP-0587194-A1 | 2-(Heterocycloalkoxy)-1-(subst.-phenyl)-ethanol derivatives as cerebral function improving agents | TOYAMA CHEMICAL CO., LTD. (JP) | 1994-03-16 | — | — | EP | disclosed |
| EP-0587193-A1 | 1,2-Ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same | TOYAMA CHEMICAL CO., LTD. (JP) | 1994-03-16 | — | — | EP | disclosed |
| US-5280032-A | 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same | TOYAMA CHEMICAL CO., LTD. (JP) | 1994-01-18 | — | — | US | disclosed |
| EP-0383281-A1 | 1,2-ethanediol derivative and salt thereof, process for producing the same, and cerebral function-improving agent comprising the same | TOYAMA CHEMICAL CO., LTD. (JP) | 1990-08-22 | — | — | EP | disclosed |