Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 5/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8523531 | 0.90 | SLC6A2 (0.34) | POLBSLC6A2SLC6A3ALDH1A1SMN1; SMN2 | |
| SCHEMBL8479995 | 0.90 | MEN1 (0.36) | TACR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8480386 | 0.86 | POLB (0.33) | POLBALDH1A1 | |
| SCHEMBL8479937 | 0.85 | MEN1 (0.35) | TACR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8501140 | 0.84 | POLB (0.35) | POLBELANEALDH1A1 | |
| SCHEMBL8653095 | 0.83 | PRMT5 (0.33) | POLB | |
| SCHEMBL8483461 | 0.80 | DRD3 (0.35) | POLBTACR1 | |
| SCHEMBL8483454 | 0.79 | MEN1 (0.35) | POLBELANEALDH1A1SMN1; SMN2 | |
| SCHEMBL8667920 | 0.76 | UBE2M (0.36) | — | |
| SCHEMBL8667993 | 0.76 | ACKR3 (0.37) | POLBSLC6A2SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883099-A | TREATMENT OF ATHERSCLEROSIS, PANCREATITIS OBESITY OR HYPERGLYCEMIA | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-16 | — | — | US | disclosed |
| US-H1729-H | Method for preparing compounds employing solid phase synthesis and novel linker-resin | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-05 | — | — | US | disclosed |