Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 13/20 | 0.48 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1183306 | 0.86 | RAPGEF4 (0.48) | RAPGEF4 | |
| SCHEMBL1193784 | 0.83 | MAPT (0.50) | RAPGEF4KMT2ANPC1RAB9APOLB | |
| SCHEMBL7068369 | 0.79 | RAPGEF4 (0.48) | RAPGEF4CRHR1 | |
| SCHEMBL4857708 | 0.79 | CRHR1 (0.49) | RAPGEF4CRHR1MEN1KMT2ANPC1 | |
| SCHEMBL10303879 | 0.78 | RAPGEF4 (0.64) | RAPGEF4 | |
| SCHEMBL18971579 | 0.77 | CHRNA7 (0.47) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL29849205 | 0.72 | MEN1 (0.47) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL3711167 | 0.72 | MEN1 (0.47) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL1183435 | 0.72 | RAPGEF4 (0.45) | RAPGEF4 | |
| SCHEMBL6093823 | 0.72 | CRHR1 (0.43) | RAPGEF4CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962479-A | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 1999-10-05 | — | — | US | disclosed |