Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 7/20 | 0.73 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.73 |
| ▸ | KDM1A | O60341 | 13/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8489010 | 0.88 | TOP2A (0.78) | TOP2ATOP2BKDM1A | |
| SCHEMBL8489028 | 0.85 | TOP2A (0.73) | TOP2ATOP2BKDM1A | |
| SCHEMBL1865418 | 0.85 | TOP2A (1.00) | TOP2ATOP2BKDM1A | |
| SCHEMBL29536689 | 0.85 | TOP2A (1.00) | TOP2ATOP2BKDM1A | |
| SCHEMBL8489125 | 0.85 | TOP2A (0.66) | TOP2ATOP2BKDM1A | |
| SCHEMBL3985902 | 0.84 | TOP2A (0.71) | TOP2ATOP2BKDM1A | |
| SCHEMBL8489781 | 0.82 | TOP2A (0.67) | TOP2ATOP2BKDM1A | |
| SCHEMBL8488702 | 0.82 | TOP2A (0.67) | TOP2ATOP2BKDM1A | |
| SCHEMBL7564567 | 0.81 | TOP2A (0.82) | TOP2ATOP2BKDM1A | |
| SCHEMBL8485322 | 0.81 | TOP2A (0.69) | TOP2ATOP2BKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939428-A | ANTITUMOR AGENTS AND ANTIGROWTH AGENTS FOR CELLS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 1999-08-17 | — | — | US | disclosed |