Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 8/20 | 0.78 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.78 |
| ▸ | KDM1A | O60341 | 9/20 | 0.55 |
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8484693 | 0.88 | TOP2A (0.73) | TOP2ATOP2BKDM1A | |
| SCHEMBL8489028 | 0.88 | TOP2A (0.73) | TOP2ATOP2BKDM1AMEN1POLB | |
| SCHEMBL1865418 | 0.88 | TOP2A (1.00) | TOP2ATOP2BKDM1AMEN1POLB | |
| SCHEMBL29536689 | 0.88 | TOP2A (1.00) | TOP2ATOP2BKDM1AMEN1POLB | |
| SCHEMBL3985902 | 0.87 | TOP2A (0.71) | TOP2ATOP2BKDM1APARP1POLB | |
| SCHEMBL8488702 | 0.84 | TOP2A (0.67) | TOP2ATOP2BKDM1APARP1CYP3A4 | |
| SCHEMBL8489781 | 0.84 | TOP2A (0.67) | TOP2ATOP2BKDM1APARP1CYP3A4 | |
| SCHEMBL7564567 | 0.84 | TOP2A (0.82) | TOP2ATOP2BKDM1AMEN1KMT2A | |
| SCHEMBL8489125 | 0.84 | TOP2A (0.66) | TOP2ATOP2BKDM1APARP1CYP3A4 | |
| SCHEMBL8485322 | 0.83 | TOP2A (0.69) | TOP2ATOP2BKDM1AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939428-A | ANTITUMOR AGENTS AND ANTIGROWTH AGENTS FOR CELLS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 1999-08-17 | — | — | US | disclosed |