SCHEMBL8486201

SCHEMBL8486201

ClC(Cl)(Cl)Sc1ccc(SC(Cl)(Cl)Cl)cc1.Sc1ccc(S)cc1

nearest known ligand 0.39

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.39
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8779804 0.86 KDM4E (0.38) KDM4EALDH1A1TDP1
SCHEMBL8488706 0.82 TSHR (0.43) ALDH1A1
SCHEMBL8488711 0.80
SCHEMBL7940598 0.74 NR1H2 (0.50) KDM4EALDH1A1TDP1
SCHEMBL15063439 0.74 SLC6A4 (0.45) IDO1KDM4EALDH1A1TDP1
SCHEMBL7938138 0.74 ALDH1A1 (0.36) KDM4EALDH1A1TDP1
SCHEMBL6933019 0.74 CYP2A6 (0.42) KDM4EALDH1A1TDP1
SCHEMBL5919354 0.74 ALDH1A1 (0.58) IDO1KDM4EALDH1A1TDP1
SCHEMBL10489143 0.72 SMN1; SMN2 (0.45) ALDH1A1
SCHEMBL23569923 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5932731-A HYDROLYZING A HETEROAROMATIC HALOGENATED METHYL SULFIDE IN PRESENCE OF AN ACID SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1999-08-03 US disclosed