Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 6/20 | 0.61 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.56 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.56 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.56 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.56 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8651887 | 1.00 | NR1H3 (0.61) | NR1H3ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8846861 | 0.81 | HSD11B1 (0.57) | ABCC9ABCC8KCNJ11KCNJ8TSHR | |
| SCHEMBL9240562 | 0.81 | HSD11B1 (0.57) | ABCC9ABCC8KCNJ11KCNJ8TSHR | |
| SCHEMBL8846896 | 0.81 | HSD11B1 (0.57) | ABCC9ABCC8KCNJ11KCNJ8TSHR | |
| SCHEMBL8846856 | 0.81 | HSD11B1 (0.57) | ABCC9ABCC8KCNJ11KCNJ8TSHR | |
| SCHEMBL8486227 | 0.78 | ABCC9 (0.53) | ABCC9ABCC8KCNJ11KCNJ8POLB | |
| SCHEMBL8486225 | 0.78 | ABCC9 (0.53) | ABCC9ABCC8KCNJ11KCNJ8POLB | |
| SCHEMBL25962408 | 0.76 | CYP2C19 (0.50) | HDAC1HDAC8TSHRHDAC3HDAC4 | |
| SCHEMBL6345171 | 0.74 | HDAC1 (0.66) | NR1H3ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL2801033 | 0.73 | CA12 (0.67) | NR1H3NR1H2HDAC1HDAC8CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999062873-A1 | BENZENESULPHONAMIDE DERIVATIVES AS PYRUVATE DEHYDROGENASE ACTIVATORS | ASTRAZENECA AB (SE) | 1999-12-09 | — | — | WO | claimed |
| EP-0625516-B1 | Benzenesulphonamide derivatives for the treatment of bladder instability | ZENECA LTD (GB) | 1998-09-09 | — | — | EP | claimed |
| WO-1999062873-A1 | BENZENESULPHONAMIDE DERIVATIVES AS PYRUVATE DEHYDROGENASE ACTIVATORS | ASTRAZENECA AB (SE) | 1999-12-09 | — | — | WO | disclosed |
| US-5693639-A | TREATING URINARY INCONTINENCE | ZENECA LIMITED (GB) | 1997-12-02 | — | — | US | disclosed |
| US-5510386-A | ADMINISTERING TO RELAX SMOOTH MUSCLE OF THE BLADDER | ZENECA LIMITED (GB) | 1996-04-23 | — | — | US | disclosed |