Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13699676 | 0.86 | CYP1A2 (0.44) | KDM4EALDH1A1HPGDL3MBTL1HSD17B10 | |
| SCHEMBL8509407 | 0.86 | KDM4E (0.53) | KDM4EALDH1A1HPGDL3MBTL1HSD17B10 | |
| Hydrochloric Acid SCHEMBL8483294 | 0.83 | KDM4E (0.44) | KDM4EALDH1A1HPGDL3MBTL1HSD17B10 | |
| SCHEMBL11233136 | 0.78 | ATM (0.54) | KDM4EHPGDL3MBTL1MCL1TDP1 | |
| SCHEMBL13699889 | 0.78 | TP53 (0.60) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL13699726 | 0.76 | MAPT (0.53) | KDM4EALDH1A1HPGDL3MBTL1HSD17B10 | |
| SCHEMBL8119758 | 0.76 | KMT2A (0.49) | KDM4EALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL13699704 | 0.75 | MAPT (0.60) | ALDH1A1HPGDHSD17B10MAPK10AHR | |
| SCHEMBL73391 | 0.75 | KDM4E (0.52) | KDM4EALDH1A1HPGDL3MBTL1HSD17B10 | |
| SCHEMBL4745049 | 0.75 | RAB9A (0.56) | KDM4EHPGDL3MBTL1MCL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955495-A | BENZOFURAN-2-CARBOXAMIDINE OR 2-CARBOXAMIDOXIME COMPOUNDS USEFUL IN THE CONTROL OR PREVENTION OF ILLNESSES OR DISORDERS OF THE CENTRAL NERVOUS SYSTEM SUCH AS MIGRAINE, SCHIZOPHRENIA, ANXIETY STATES, SLEEP DISORDERS, ANOREXIA, ALZHEIMER'S | HOFFMANN-LA ROCHE INC. (US) | 1999-09-21 | — | — | US | disclosed |
| EP-0906301-A1 | BENZOFURYL DERIVATIVES AND THEIR USE | F. HOFFMANN-LA ROCHE AG (CH) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997042183-A1 | BENZOFURYL DERIVATIVES AND THEIR USE | F. HOFFMANN-LA ROCHE AG (CH) | 1997-11-13 | — | — | WO | disclosed |