Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.46 |
| ▸ | PDE4A | P27815 | 9/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8488126 | 0.82 | PDE4B (0.51) | PDE4BPDE4DPDE4APDE4CTP53 | |
| SCHEMBL8484879 | 0.79 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4CAKR1B1 | |
| SCHEMBL8486551 | 0.78 | PDE4B (0.47) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8484115 | 0.76 | PDE4B (0.46) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7170243 | 0.72 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4CALDH1A1 | |
| SCHEMBL7170246 | 0.72 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4CALDH1A1 | |
| SCHEMBL6584635 | 0.72 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7760278 | 0.71 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4CTP53 | |
| SCHEMBL7763958 | 0.71 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4CTP53 | |
| SCHEMBL7764115 | 0.71 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4CTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5783591-A | Administration of oxazolidinone and pyrolidinone compounds for the treatment of inflammation | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-07-21 | — | — | US | claimed |
| EP-0198919-B1 | PHARMACEUTICAL PREPARATIONS | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-02-28 | — | — | EP | claimed |
| EP-0198919-A1 | PHARMACEUTICAL PREPARATIONS. | SCHERING AG (DE) | 1986-10-29 | — | — | EP | claimed |
| WO-1986002268-A1 | PHARMACEUTICAL PREPARATIONS | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1986-04-24 | — | — | WO | claimed |
| US-5998453-A | ANTIINFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-12-07 | — | — | US | disclosed |
| US-5783591-A | Administration of oxazolidinone and pyrolidinone compounds for the treatment of inflammation | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-07-21 | — | — | US | disclosed |
| EP-0198919-B1 | PHARMACEUTICAL PREPARATIONS | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-02-28 | — | — | EP | disclosed |