Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.82 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.82 |
| ▸ | PDE4A | P27815 | 5/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7760278 | 1.00 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| SCHEMBL7763958 | 1.00 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| Daxalipram SCHEMBL450824 | 0.90 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| Daxalipram SCHEMBL450823 | 0.90 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| Daxalipram SCHEMBL7760245 | 0.90 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| SCHEMBL11435807 | 0.90 | PDE4B (0.77) | PDE4BPDE4DPDE4APDE4CKMT2A | |
| SCHEMBL8489189 | 0.89 | PDE4B (0.89) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| SCHEMBL7763217 | 0.88 | PDE4B (0.75) | PDE4BPDE4DPDE4APDE4CIGF1R | |
| SCHEMBL7764133 | 0.88 | PDE4B (0.75) | PDE4BPDE4DPDE4APDE4CIGF1R | |
| SCHEMBL8486187 | 0.86 | PDE4B (0.72) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0859766-B1 | CHIRAL METHYL PHENYL OXAZOLIDINONES | SCHERING AG (DE) | 2001-05-16 | — | — | EP | disclosed |
| US-6025376-A | INHIBITORS OF TUMOR NECROSIS FACTOR, TREATING MULTIPLE SCLEROSIS | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |
| EP-0859766-A1 | CHIRAL METHYL PHENYL OXAZOLIDINONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-26 | — | — | EP | disclosed |
| WO-1997015561-A1 | CHIRAL METHYL PHENYL OXAZOLIDINONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |