Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | NQO1 | P15559 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 8/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8486344 | 0.87 | TOP2A (0.40) | KMT2ASMN1; SMN2TDP1MAPTNSD2 | |
| SCHEMBL8487902 | 0.87 | MAPT (0.35) | KMT2ASMN1; SMN2MEN1TDP1NQO1 | |
| SCHEMBL8485535 | 0.86 | NQO1 (0.36) | KMT2ASMN1; SMN2MEN1TDP1NQO1 | |
| SCHEMBL8485482 | 0.86 | NQO1 (0.41) | KMT2ASMN1; SMN2MEN1TDP1NQO1 | |
| SCHEMBL8487670 | 0.84 | TOP2A (0.41) | KMT2ASMN1; SMN2MEN1TDP1NQO1 | |
| SCHEMBL8483655 | 0.83 | — | — | |
| SCHEMBL8487874 | 0.81 | NQO1 (0.35) | NQO1MAPTHTT | |
| SCHEMBL8489284 | 0.81 | NQO1 (0.35) | KMT2ASMN1; SMN2MEN1TDP1NQO1 | |
| SCHEMBL10815526 | 0.74 | TOP2A (0.37) | SMN1; SMN2NQO1MAPTALDH1A1LMNA | |
| SCHEMBL10811696 | 0.73 | NQO1 (0.33) | NQO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935969-A | Pyrido-thiopyrandoinazoles with antitumor activity | UNIVERSITY OF VERMONT (US) | 1999-08-10 | — | — | US | disclosed |