Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8483307 | 0.91 | THRB (0.37) | THRBMAPTPOLBLMNATOP2A | |
| SCHEMBL8485927 | 0.89 | TOP2A (0.47) | THRBMAPTPOLBLMNATOP2A | |
| SCHEMBL8486910 | 0.86 | HDAC1 (0.32) | LMNAHDAC1RXFP1 | |
| SCHEMBL8487456 | 0.82 | DYRK1A (0.35) | POLBTOP2A | |
| SCHEMBL8488681 | 0.82 | DYRK1A (0.36) | POLBTOP2A | |
| SCHEMBL8486027 | 0.81 | TOP2A (0.32) | TOP2A | |
| SCHEMBL8488277 | 0.77 | TOP2A (0.31) | MAPTTOP2A | |
| SCHEMBL8485791 | 0.77 | NQO1 (0.36) | MAPTPOLBLMNATOP2AMEN1 | |
| SCHEMBL8482764 | 0.77 | TOP2A (0.34) | TOP2A | |
| SCHEMBL8483473 | 0.76 | TOP2A (0.42) | TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935969-A | Pyrido-thiopyrandoinazoles with antitumor activity | UNIVERSITY OF VERMONT (US) | 1999-08-10 | — | — | US | disclosed |