Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | PARP1 | P09874 | 7/20 | 0.53 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10487972 | 0.86 | KDM4E (0.62) | KDM4EKMT2APARP1ALDH1A1HSD17B10 | |
| SCHEMBL11983439 | 0.84 | PARP1 (0.56) | KDM4EPARP1PARP2 | |
| SCHEMBL7231747 | 0.82 | KDM4E (0.67) | KDM4ESMN1; SMN2KMT2AALDH1A1HSD17B10 | |
| SCHEMBL8377270 | 0.82 | KDM4E (0.64) | KDM4EPARP1ALDH1A1 | |
| SCHEMBL22693613 | 0.82 | PARP1 (0.56) | KDM4EKMT2APARP1TSHRMEN1 | |
| SCHEMBL3202252 | 0.81 | KDM4E (0.69) | KDM4ESMN1; SMN2KMT2AALDH1A1HSD17B10 | |
| SCHEMBL8432918 | 0.81 | CBX7 (0.47) | KDM4ESMN1; SMN2KMT2APARP1PARP2 | |
| SCHEMBL12912986 | 0.79 | KDM4E (0.58) | KDM4ESMN1; SMN2KMT2AALDH1A1HSD17B10 | |
| SCHEMBL8890391 | 0.79 | HDAC6 (0.58) | KDM4ESMN1; SMN2KMT2AALDH1A1HSD17B10 | |
| SCHEMBL3697079 | 0.78 | PARP1 (0.47) | KDM4ESMN1; SMN2PARP1PARP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001831-A | Process for producing quinazoline derivatives | CLARIANT GMBH (DE) | 1999-12-14 | — | — | US | disclosed |
| WO-1997002254-A1 | QUINAZOLINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-23 | — | — | WO | disclosed |