Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | PRKACG | P22612 | 1/20 | 0.51 |
| ▸ | PRKACB | P22694 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 5/20 | 0.51 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22693613 | 0.87 | PARP1 (0.56) | KDM4EGLALCKPRKACACSNK2A2 | |
| SCHEMBL11983439 | 0.86 | PARP1 (0.56) | KDM4EGLALCKPRKACACSNK2A2 | |
| SCHEMBL13799882 | 0.84 | FABP4 (0.66) | KDM4EAPEX1LCKPRKACACSNK2A2 | |
| SCHEMBL3540980 | 0.84 | KDM4E (0.60) | KDM4EGLAAPEX1LCKPRKACA | |
| SCHEMBL7300140 | 0.82 | FABP4 (0.68) | KDM4ELCKPRKACACSNK2A2PRKACG | |
| SCHEMBL8487616 | 0.82 | KDM4E (0.59) | KDM4EPARP1ALDH1A1 | |
| SCHEMBL2255490 | 0.80 | MEN1 (0.62) | KDM4EGLAAPEX1ALDH1A1MAPK1 | |
| SCHEMBL10487972 | 0.80 | KDM4E (0.62) | KDM4EPARP1ALDH1A1 | |
| SCHEMBL8046411 | 0.79 | MAT2A (0.52) | AKR1B10AKR1B1 | |
| SCHEMBL8890567 | 0.79 | HDAC1 (0.47) | KDM4EGLAAPEX1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001831-A | Process for producing quinazoline derivatives | CLARIANT GMBH (DE) | 1999-12-14 | — | — | US | claimed |
| EP-0847392-B1 | PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVES | CLARIANT GMBH (DE) | 1999-12-08 | — | — | EP | claimed |
| EP-2768822-B1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARM SPA (IT) | 2017-12-06 | — | — | EP | disclosed |
| US-9024027-B2 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-05-05 | — | — | US | disclosed |
| US-9024027-B2 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2015-05-05 | — | — | US | disclosed |
| US-20130102576-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-04-25 | — | — | US | disclosed |
| US-20130102576-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-04-25 | — | — | US | disclosed |
| US-6001831-A | Process for producing quinazoline derivatives | CLARIANT GMBH (DE) | 1999-12-14 | — | — | US | disclosed |
| US-6001831-A | Process for producing quinazoline derivatives | CLARIANT GMBH (DE) | 1999-12-14 | — | — | US | disclosed |
| EP-0847392-B1 | PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVES | CLARIANT GMBH (DE) | 1999-12-08 | — | — | EP | disclosed |
| US-5973189-A | Monoesters of carboxymethylene anthranilic acids and process for preparing the same | CLARIANT GMBH (DE) | 1999-10-26 | — | — | US | disclosed |
| CN-1194639-A | Quinazoline derivatives and their use as anti-inflammatory agents | CORIEN CO LTD (DE) | 1998-09-30 | — | — | CN | disclosed |
| EP-0847392-A1 | PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVES | Clariant GmbH (DE) | 1998-06-17 | — | — | EP | disclosed |
| WO-1997008154-A1 | PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVES | CLARIANT GMBH (DE) | 1997-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130102576-A1 | DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE3A, PDE4B | KDM4E 1220/4885GLA 852/4885APEX1 602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.