SCHEMBL8487646

SCHEMBL8487646

C=CCc1c([C]=O)cccc1C(=O)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.41
ALDH1A1 P00352 3/20 0.39
LMNA P02545 1/20 0.39
HPGD P15428 1/20 0.39
MAPT P10636 3/20 0.39
GAA P10253 1/20 0.39
ATM Q13315 2/20 0.36
TDP1 Q9NUW8 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
ELANE P08246 1/20 0.36
SRD5A1 P18405 1/20 0.35
AKT1 P31749 1/20 0.35
CDC25B P30305 1/20 0.34
CYP3A4 P08684 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8081801 0.82 AKR1C3 (0.55) AKR1C3ALDH1A1LMNAHPGDMAPT
SCHEMBL253177 0.81 LIG1 (0.45) AKR1C3ALDH1A1LMNAHPGDMAPT
SCHEMBL474923 0.81 AKR1C3 (0.44) AKR1C3ALDH1A1LMNAHPGDMAPT
SCHEMBL2212691 0.79 MAPT (0.57) AKR1C3ALDH1A1LMNAHPGDMAPT
SCHEMBL15796982 0.79 AKR1C3 (0.43) AKR1C3ALDH1A1LMNAHPGDMAPT
SCHEMBL64069 0.76 AKR1C3 (0.57) AKR1C3ALDH1A1LMNAMAPTGAA
SCHEMBL1331831 0.76 AKR1C3 (0.57) AKR1C3ALDH1A1LMNAMAPTGAA
SCHEMBL30581210 0.76 ELANE (0.44) AKR1C3ALDH1A1LMNAHPGDMAPT
SCHEMBL10657458 0.75 AKR1C3 (0.52) AKR1C3ALDH1A1MAPTGAAATM
Benzophenone SCHEMBL28421417 0.74 ELANE (0.41) AKR1C3ALDH1A1LMNAHPGDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999015174-A1 REVERSE PRENYL COMPOUNDS AS IMMUNOSUPPRESSANTS SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1999-04-01 WO claimed
WO-1999015174-A1 REVERSE PRENYL COMPOUNDS AS IMMUNOSUPPRESSANTS SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1999-04-01 WO disclosed