Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | NMBR | P28336 | 5/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.46 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.46 |
| ▸ | BRS3 | P32247 | 6/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8487755 | 1.00 | HRH4 (0.48) | HRH4NMBRFNTAPGGT1BBRS3 | |
| SCHEMBL8485136 | 0.93 | FNTA (0.47) | HRH4NMBRFNTAPGGT1BCTSS | |
| SCHEMBL8485139 | 0.93 | FNTA (0.47) | HRH4NMBRFNTAPGGT1BCTSS | |
| SCHEMBL8485028 | 0.90 | KMT2A (0.53) | FNTAPGGT1BCA2 | |
| SCHEMBL8485023 | 0.90 | KMT2A (0.53) | FNTAPGGT1BCA2 | |
| SCHEMBL8486463 | 0.90 | HRH4 (0.44) | HRH4FNTAPGGT1BCTSSCTSK | |
| SCHEMBL8486470 | 0.90 | HRH4 (0.44) | HRH4FNTAPGGT1BCTSSCTSK | |
| SCHEMBL10872017 | 0.89 | HRH4 (0.50) | HRH4CYP3A4 | |
| SCHEMBL8481703 | 0.89 | REN (0.43) | HRH4FNTAPGGT1BCTSSCTSK | |
| SCHEMBL8481701 | 0.89 | REN (0.43) | HRH4FNTAPGGT1BCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6008372-A | ANTICARCINOGENIC, ANTIRESTENOSIS AND ANTIPSORIASIS AGENT | WARNER-LAMBERT COMPANY (US) | 1999-12-28 | — | — | US | claimed |
| WO-1997026246-A1 | SUBSTITUTED HISTIDINE INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1997-07-24 | — | — | WO | claimed |
| US-6008372-A | ANTICARCINOGENIC, ANTIRESTENOSIS AND ANTIPSORIASIS AGENT | WARNER-LAMBERT COMPANY (US) | 1999-12-28 | — | — | US | disclosed |
| WO-1997026246-A1 | SUBSTITUTED HISTIDINE INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1997-07-24 | — | — | WO | disclosed |