Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28777414 | 0.98 | KDM4E (0.35) | KDM4EKMT2AALOX15OPRM1SIGMAR1 | |
| SCHEMBL6092390 | 0.83 | — | — | |
| SCHEMBL3844048 | 0.78 | KDM4E (0.38) | KDM4EKMT2AOPRM1SIGMAR1CYP1A2 | |
| SCHEMBL27664279 | 0.78 | — | — | |
| SCHEMBL8401641 | 0.78 | ALOX15 (0.33) | ALOX15 | |
| SCHEMBL7405510 | 0.77 | KDM4E (0.41) | KDM4EKMT2AOPRM1CYP1A2 | |
| SCHEMBL27689252 | 0.77 | KDM4E (0.36) | KDM4EKMT2AALOX15OPRM1CYP1A2 | |
| SCHEMBL28515873 | 0.77 | KDM4E (0.41) | KDM4EKMT2A | |
| SCHEMBL28609456 | 0.77 | KDM4E (0.41) | KDM4EKMT2ACYP1A2 | |
| SCHEMBL4225849 | 0.76 | SMN1; SMN2 (0.33) | KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101565420-B | Limk2 inhibitors, compositions comprising them, and methods of their use | LEXICON PHARMACEUTICALS INC | 2015-05-20 | — | — | CN | disclosed |
| CN-104619709-A | Imidazopyridine derivatives as modulators of TNF activity | UCB PHARMA SA | 2015-05-13 | — | — | CN | disclosed |
| CN-101565420-A | LIMK2 inhibitors, compositions comprising them, and methods of their use | LEXICON PHARMACEUTICALS INC (US) | 2009-10-28 | — | — | CN | disclosed |
| CN-101052625-A | As P2X7Adamantyl derivatives of receptor antagonists | ASTRAZENECA AB (SE) | 2007-10-10 | — | — | CN | disclosed |
| WO-1999065881-A1 | HETEROCYCLIC COMPOUNDS AS HYPOGLYCEMIC AGENTS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1999-12-23 | — | — | WO | disclosed |