SCHEMBL8488050

SCHEMBL8488050

C[Si](C)(C)CCOCc1[nH]c(S(=O)(=O)c2ccccc2)nc1CCC1CCCCC1

nearest known ligand 0.39

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
FFAR2 O15552 16/20 0.39
CNR2 P34972 1/20 0.35
RAB9A P51151 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8489723 0.77 FFAR2 (0.33) FFAR2
SCHEMBL8488040 0.76 HTT (0.35) FFAR2L3MBTL1
SCHEMBL8492036 0.76 ABCB1 (0.32) FFAR2
SCHEMBL8489958 0.74 FFAR2 (0.34) FFAR2
SCHEMBL8489720 0.73 FFAR2 (0.33) FFAR2
SCHEMBL4726440 0.68 ABCB1 (0.36) FFAR2
SCHEMBL8486725 0.67 ABCB1 (0.33) FFAR2L3MBTL1
SCHEMBL4728358 0.65 AKT1 (0.36)
SCHEMBL8488898 0.64 DAO (0.34)
SCHEMBL27858590 0.59 EPHX2 (0.48)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999006377-A1 DERIVATIVES OF 1-((3,3-DIMETHYL-3-SILABUTOXY)METHYL)-2-(PHENYLSULFONYL)IMIDAZOLE GLIATECH, INC. (US) 1999-02-11 WO disclosed