Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 6/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8489958 | 0.79 | FFAR2 (0.34) | ABCB1ABCC1ALDH1A1MAPTFFAR2 | |
| SCHEMBL8488040 | 0.72 | HTT (0.35) | ABCB1TDP1ALDH1A1MAPTTSHR | |
| SCHEMBL8492036 | 0.72 | ABCB1 (0.32) | ABCB1ABCC1ALDH1A1MAPTFFAR2 | |
| SCHEMBL8486725 | 0.69 | ABCB1 (0.33) | ABCB1ABCC1ALDH1A1MAPTTSHR | |
| SCHEMBL4728358 | 0.69 | AKT1 (0.36) | CCNE1CDK2TDP1ALDH1A1HPGD | |
| SCHEMBL4890258 | 0.68 | ABCB1 (0.39) | ABCB1CCNE2CCNE1CDK2ABCC1 | |
| SCHEMBL8488050 | 0.68 | FFAR2 (0.39) | FFAR2 | |
| SCHEMBL5284320 | 0.60 | MAPK1 (0.43) | TDP1MAPTTSHRLMNAHTT | |
| SCHEMBL29669045 | 0.58 | ALDH1A1 (0.56) | TDP1ALDH1A1MAPTTSHRKDM4E | |
| SCHEMBL6997572 | 0.58 | NPC1 (0.39) | ALDH1A1HPGDGAATSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008036308-A2 | AMINO-SUBSTITUTED HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-03-27 | — | — | WO | disclosed |