Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 18/20 | 0.64 |
| ▸ | MAPK12 | P53778 | 17/20 | 0.64 |
| ▸ | MAPK11 | Q15759 | 17/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.64 |
| ▸ | RAF1 | P04049 | 3/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | AKT2 | P31751 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | FRK | P42685 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7695632 | 0.83 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL8484311 | 0.80 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7215450 | 0.80 | MAPK14 (0.82) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL7215445 | 0.80 | MAPK14 (0.82) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL14561106 | 0.79 | MAPK13 (0.60) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL14561108 | 0.79 | MAPK13 (0.60) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL8488146 | 0.79 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5818671 | 0.79 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6215621 | 0.79 | MAPK14 (0.79) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6171137 | 0.79 | MAPK14 (0.84) | MAPK14MAPK13MAPK12MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859041-A | Substituted imidazoles having cytokine inhibitory activity | MERCK & CO., INC. (US) | 1999-01-12 | — | — | US | disclosed |