Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8486316 | 0.82 | PPARA (0.52) | KMT2AMEN1PPARACA12CA1 | |
| SCHEMBL18573443 | 0.78 | ALDH1A1 (0.56) | KMT2AMEN1PPARARAB9AALDH1A1 | |
| Bromide SCHEMBL18553827 | 0.77 | ALDH1A1 (0.55) | KMT2AMEN1PPARARAB9AALDH1A1 | |
| SCHEMBL10334172 | 0.76 | ALDH1A1 (0.61) | PGRAKR1C3ALDH1A1CYP2C19 | |
| SCHEMBL10334227 | 0.76 | ALDH1A1 (0.61) | PGRAKR1C3ALDH1A1CYP2C19 | |
| SCHEMBL10334427 | 0.76 | ALDH1A1 (0.61) | PGRAKR1C3ALDH1A1CYP2C19 | |
| SCHEMBL10333940 | 0.76 | ALDH1A1 (0.61) | PGRAKR1C3ALDH1A1CYP2C19 | |
| SCHEMBL1876555 | 0.76 | ALDH1A1 (0.71) | KMT2AMEN1ALDH1A1PKMLMNA | |
| SCHEMBL9870700 | 0.74 | FABP4 (0.77) | ALDH1A1PKMLMNAFBP1 | |
| SCHEMBL9871347 | 0.74 | FABP4 (0.77) | ALDH1A1PKMLMNAFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877196-A | N- 4-(imidazolyl or pyrazolyl)phenyl(oxy, sulfinyl, sulfenyl or sulfonyl)alkyl!carboxamides, sulfonamides or phosphoramides having antiarrhythmic properties | AMERICAN CYANAMID COMPANY (US) | 1999-03-02 | — | — | US | disclosed |
| EP-0792873-A1 | N-(Phenoxyalkyl) carboxamides and their use as antiarrhythmic agents | American Cyanamid Company (US) | 1997-09-03 | — | — | EP | disclosed |