Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 10/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8488939 | 0.92 | NAMPT (0.35) | NAMPTKMT2AKDM4EALDH1A1ALOX15 | |
| SCHEMBL8485019 | 0.91 | NAMPT (0.42) | NAMPTKMT2AKDM4EALDH1A1ALOX15 | |
| SCHEMBL8486426 | 0.88 | NAMPT (0.41) | NAMPTKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL8488436 | 0.86 | NAMPT (0.40) | NAMPTKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL8489290 | 0.86 | KMT2A (0.36) | NAMPTKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL8488360 | 0.83 | NAMPT (0.40) | NAMPTKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL9249466 | 0.82 | NAMPT (0.47) | NAMPT | |
| SCHEMBL8488725 | 0.76 | MAPT (0.38) | KMT2AKDM4EMEN1ALDH1A1POLB | |
| SCHEMBL8489294 | 0.75 | NAMPT (0.36) | NAMPTKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL9298837 | 0.75 | NAMPT (0.43) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955463-A | ANTITUMOR, ANTIINFLAMMATORY, AND ANTIARTHRITIC AGENTS | ZENECA LIMITED (GB) | 1999-09-21 | — | — | US | disclosed |