Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.62 |
| ▸ | RAB9A | P51151 | 8/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.60 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8795071 | 0.88 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2HPGDADRB2 | |
| SCHEMBL11433155 | 0.81 | NPC1 (0.93) | NPC1RAB9ASMN1; SMN2HPGDMEN1 | |
| SCHEMBL1578277 | 0.78 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2HPGDMEN1 | |
| SCHEMBL16556594 | 0.77 | KDM4E (0.63) | SMN1; SMN2HPGDKDM4EALDH1A1MEN1 | |
| SCHEMBL3555970 | 0.77 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2HPGDAR | |
| SCHEMBL2217897 | 0.77 | NPC1 (0.79) | NPC1RAB9ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL11135666 | 0.77 | DRD2 (0.67) | NPC1RAB9ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL11133311 | 0.77 | DRD2 (0.59) | NPC1RAB9ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL9733253 | 0.77 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL11696035 | 0.77 | GRIN1 (0.55) | NPC1RAB9ASMN1; SMN2HPGDADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877196-A | N- 4-(imidazolyl or pyrazolyl)phenyl(oxy, sulfinyl, sulfenyl or sulfonyl)alkyl!carboxamides, sulfonamides or phosphoramides having antiarrhythmic properties | AMERICAN CYANAMID COMPANY (US) | 1999-03-02 | — | — | US | disclosed |