SCHEMBL8488500

SCHEMBL8488500

CN(C(=O)C(Cc1ccc(C#N)cc1)NS(=O)(=O)c1ccc2ccccc2c1)C1CCCCC1

nearest known ligand 0.78

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F2 P00734 16/20 0.78
PRSS1 P07477 2/20 0.72
F10 P00742 2/20 0.72
PLG P00747 1/20 0.72
PLAT P00750 1/20 0.72
PRSS2 P07478 1/20 0.72
PRSS3 P35030 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7015978 1.00 F2 (0.78) F2PRSS1F10PLGPLAT
SCHEMBL7017283 0.99 F2 (0.79) F2PRSS1F10PLGPLAT
SCHEMBL7017279 0.99 F2 (0.79) F2PRSS1F10PLGPLAT
SCHEMBL8489778 0.96 F2 (0.73) F2PRSS1F10PLGPLAT
SCHEMBL7023038 0.96 F2 (0.73) F2PRSS1F10PLGPLAT
SCHEMBL7020745 0.90 F2 (0.64) F2PRSS1F10PLGPLAT
SCHEMBL8490042 0.90 F2 (0.64) F2PRSS1F10PLGPLAT
SCHEMBL7025792 0.89 F2 (0.69) F2PRSS1F10PLGPLAT
SCHEMBL7025799 0.89 F2 (0.69) F2PRSS1F10PLGPLAT
SCHEMBL7021171 0.89 F2 (0.64) F2PRSS1F10PLGPLAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5985899-A ANTICOAGULANTS LG CHEMICAL LTD. (KR) 1999-11-16 US disclosed
WO-1997049673-A1 SELECTIVE THROMBIN INHIBITORS LG CHEMICAL LTD. (KR) 1997-12-31 WO disclosed