Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 7/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8483534 | 0.93 | LTB4R2 (0.37) | PTGDR2AGTR1LTB4R2PKMAGTR2 | |
| SCHEMBL8488532 | 0.92 | AGTR1 (0.37) | PTGDR2AGTR1LTB4R2PKMAGTR2 | |
| SCHEMBL9079124 | 0.91 | LTB4R2 (0.36) | PTGDR2AGTR1LTB4R2PKMAGTR2 | |
| SCHEMBL8809843 | 0.90 | PTGDR2 (0.34) | PTGDR2AGTR1LTB4R2PKMAGTR2 | |
| SCHEMBL8486732 | 0.90 | AGTR1 (0.41) | PTGDR2AGTR1LTB4R2PKMAGTR2 | |
| SCHEMBL8486854 | 0.89 | AGTR1 (0.37) | PTGDR2AGTR1LTB4R2PKMAGTR2 | |
| SCHEMBL8809429 | 0.89 | AGTR1 (0.36) | PTGDR2AGTR1LTB4R2PKMAGTR2 | |
| SCHEMBL8485119 | 0.88 | PTGDR2 (0.35) | PTGDR2AGTR1LTB4R2PKMAGTR2 | |
| SCHEMBL8486859 | 0.88 | LTB4R2 (0.34) | PTGDR2AGTR1LTB4R2PKMALDH1A1 | |
| SCHEMBL8806931 | 0.88 | AGTR1 (0.35) | PTGDR2AGTR1LTB4R2PKMAGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955487-A | TREATING HIGH BLOOD PRESSURE, CARDIAC INSUFFICIENCY, GLAUCOMA | CIBA-GEIGY CORPORATION (US) | 1999-09-21 | — | — | US | disclosed |
| US-5620998-A | CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |
| US-5506240-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |