Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 10/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 8/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1809623 | 0.84 | AGTR1 (0.54) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL2140 | 0.84 | AGTR1 (0.54) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL29378073 | 0.84 | AGTR1 (0.54) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL8483523 | 0.84 | AGTR1 (0.46) | AGTR1LTB4R2ABCB11GP6KIF11 | |
| SCHEMBL8807370 | 0.83 | AGTR1 (0.41) | AGTR1LTB4R2ABCB11GP6CXCR3 | |
| SCHEMBL8483362 | 0.83 | AGTR1 (0.41) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL8483566 | 0.83 | FFAR1 (0.42) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL2441623 | 0.81 | AGTR1 (0.47) | AGTR1LTB4R2ABCB11GP6 | |
| SCHEMBL8487504 | 0.79 | AGTR1 (0.56) | AGTR1LTB4R2ABCB11GP6TSHR | |
| SCHEMBL8808708 | 0.78 | CTSL (0.37) | MAPTMEN1USP2PABPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955487-A | TREATING HIGH BLOOD PRESSURE, CARDIAC INSUFFICIENCY, GLAUCOMA | CIBA-GEIGY CORPORATION (US) | 1999-09-21 | — | — | US | disclosed |
| EP-0528762-B1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA GEIGY AG (CH) | 1997-05-07 | — | — | EP | disclosed |
| US-5620998-A | CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |
| US-5506240-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0528762-A1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA-GEIGY AG (CH) | 1993-02-24 | — | — | EP | disclosed |