Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.40 |
| ▸ | CPT2 | P23786 | 3/20 | 0.39 |
| ▸ | CPT1A | P50416 | 3/20 | 0.39 |
| ▸ | CPT1B | Q92523 | 2/20 | 0.39 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | F2R | P25116 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8487384 | 0.86 | BTK (0.45) | BTKTMEM97SIGMAR1CPT2CPT1A | |
| SCHEMBL8821912 | 0.83 | SIGMAR1 (0.49) | BTKTMEM97SIGMAR1CPT2CPT1A | |
| SCHEMBL8487974 | 0.81 | CPT2 (0.43) | BTKTMEM97SIGMAR1CPT2CPT1A | |
| SCHEMBL8604095 | 0.77 | BTK (0.47) | BTKTMEM97SIGMAR1CPT2CPT1A | |
| SCHEMBL8603751 | 0.77 | BTK (0.47) | BTKTMEM97SIGMAR1CPT2CPT1A | |
| SCHEMBL8491343 | 0.77 | BTK (0.45) | BTKTMEM97SIGMAR1CPT2CPT1A | |
| SCHEMBL8485395 | 0.76 | BTK (0.44) | BTKTMEM97SIGMAR1CPT2CPT1A | |
| SCHEMBL8488861 | 0.76 | BTK (0.43) | BTKTMEM97SIGMAR1CPT2CPT1A | |
| SCHEMBL8605126 | 0.74 | BTK (0.46) | BTKTMEM97SIGMAR1CPT2CPT1A | |
| SCHEMBL8488352 | 0.73 | BTK (0.44) | BTKTMEM97SIGMAR1CPT2CPT1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5859041-A | Substituted imidazoles having cytokine inhibitory activity | MERCK & CO., INC. (US) | 1999-01-12 | — | — | US | disclosed |