SCHEMBL8488998

SCHEMBL8488998

CC(C)C(=O)CC(=O)c1ccc(S(C)(=O)=O)c(Cl)c1Cl

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.41
CYP3A4 P08684 2/20 0.41
CYP2D6 P10635 2/20 0.41
CYP2C19 P33261 2/20 0.41
MAPT P10636 1/20 0.41
CYP2C9 P11712 1/20 0.41
HPGD P15428 1/20 0.41
ATM Q13315 1/20 0.41
ALDH1A1 P00352 3/20 0.40
THRB P10828 5/20 0.39
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
LMNA P02545 1/20 0.38
HTT P42858 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ADRA1D P25100 1/20 0.33
ERCC5 P28715 1/20 0.33
FEN1 P39748 1/20 0.33
SLC9A1 P19634 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8493511 0.84 CYP1A2 (0.43) CYP1A2CYP3A4CYP2D6CYP2C19MAPT
SCHEMBL8489386 0.83 IKBKB (0.41) CYP1A2CYP3A4CYP2D6CYP2C19MAPT
SCHEMBL8493014 0.78 CYP1A2 (0.39) CYP1A2CYP3A4CYP2D6CYP2C19MAPT
SCHEMBL8609011 0.77 CYP1A2 (0.38) CYP1A2CYP3A4CYP2D6CYP2C19MAPT
SCHEMBL7807426 0.75 LMNA (0.47) CYP1A2CYP3A4CYP2D6CYP2C19MAPT
SCHEMBL6101293 0.75 CYP1A2 (0.41) CYP1A2CYP3A4CYP2D6CYP2C19MAPT
SCHEMBL8489320 0.75 LMNA (0.49) CYP2C19MAPTALDH1A1MEN1KMT2A
SCHEMBL8489289 0.74 CYP1A2 (0.36) CYP1A2CYP3A4CYP2D6CYP2C19MAPT
SCHEMBL8488732 0.72 MAPK8 (0.35) CYP1A2CYP3A4CYP2D6CYP2C19MAPT
SCHEMBL8491940 0.69 ALDH1A1 (0.36) CYP1A2CYP3A4CYP2D6CYP2C19MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5859283-A TERTIARY-BUTYL 3-CYCLOALKYL-3-OXOPROPIONATE RHONE-POULENC AGRICULTURE LIMITED (GB) 1999-01-12 US disclosed
US-5747424-A HEATING AN AROMATIC DIKETONE WITH A SALT OF HYDROXYLAMINE IN A SOLVENT RHONE-POULENC AGRICULTURE LTD. (GB) 1998-05-05 US disclosed
US-5656573-A Herbicidal 4-substituted isoxazoles RHONE-POULENC AGRICULTURE LTD. (GB) 1997-08-12 US disclosed
US-5650533-A Intermediates to herbicidal 4-substituted isoxazoles RHONE-POULENC AGRICULTURE LTD. (GB) 1997-07-22 US disclosed
EP-0418175-B1 Isoxazoles herbicides RHONE POULENC AGRICULTURE (GB) 1996-07-17 EP disclosed
EP-0418175-A2 Isoxazoles herbicides RHONE POULENC AGRICULTURE LTD. (GB) 1991-03-20 EP disclosed