Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 14/20 | 0.61 |
| ▸ | CSNK1E | P49674 | 9/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.61 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | FRK | P42685 | 1/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.54 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7856399 | 0.89 | MAP4K4 (0.69) | CSNK1DCSNK1EMAPK14MAPK11MAPK13 | |
| SCHEMBL27907019 | 0.85 | MAPK14 (0.56) | CSNK1DCSNK1EMAPK14MAPK11MAPK13 | |
| SCHEMBL5257540 | 0.76 | CSNK1D (1.00) | CSNK1DCSNK1EMAPK14MAPK11MAPK13 | |
| SCHEMBL5698604 | 0.76 | CSNK1D (1.00) | CSNK1DCSNK1EMAPK14MAPK11MAPK13 | |
| SCHEMBL8112773 | 0.74 | MAP4K4 (0.51) | CSNK1DCSNK1EMAPK14MAPK11MAPK13 | |
| SCHEMBL5526916 | 0.74 | MAP4K4 (0.51) | CSNK1DCSNK1EMAPK14MAPK11MAPK13 | |
| SCHEMBL31039970 | 0.73 | TGFBR1 (0.59) | MAPK14TGFBR1THRB | |
| SCHEMBL12763678 | 0.73 | TGFBR1 (0.52) | MAPK14TGFBR1THRB | |
| SCHEMBL18579243 | 0.72 | MAPK14 (0.62) | MAPK14MAPK11MAPK13MAPK12TGFBR1 | |
| SCHEMBL3247895 | 0.72 | TGFBR1 (0.68) | CSNK1DMAPK14CSNK1A1TGFBR1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5932576-A | USEFUL FOR TREATING P38 KINASE MEDIATED DISORDERS SUCH AS ATHEROSCLEROSIS, RHEUMATIOD ARTHRITIS, INFLAMMATORY BOWEL DISEASE, PSORIASIS AND OTHERS | G. D. SEARLE & COMPANY (US) | 1999-08-03 | — | — | US | disclosed |