SCHEMBL8489274

SCHEMBL8489274

CSc1ccc(C(=O)c2cnoc2C2CC2)c(SC)c1C

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.35
PDE2A O00408 1/20 0.35
HPGD P15428 2/20 0.34
ALDH1A1 P00352 1/20 0.34
CASP3 P42574 1/20 0.34
RAB9A P51151 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
SENP8 Q96LD8 1/20 0.34
SENP7 Q9BQF6 1/20 0.34
SENP6 Q9GZR1 1/20 0.34
TAS1R3 Q7RTX0 1/20 0.33
TAS1R1 Q7RTX1 1/20 0.33
TAS1R2 Q8TE23 1/20 0.33
CRACR2A Q9BSW2 3/20 0.32
LMNA P02545 1/20 0.32
AR P10275 2/20 0.31
EPHX2 P34913 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9069970 0.90 DHODH (0.36) DHODHPDE2AHPGDALDH1A1CASP3
SCHEMBL8605928 0.89 DHODH (0.36) DHODHPDE2AHPGDALDH1A1CASP3
SCHEMBL8492889 0.87 PDE2A (0.36) DHODHPDE2AHPGDALDH1A1CASP3
SCHEMBL9114737 0.86 TUBB4A (0.35) DHODHPDE2AHPGDALDH1A1CASP3
SCHEMBL9069997 0.85 RAB9A (0.36) DHODHPDE2AHPGDALDH1A1CASP3
SCHEMBL8391520 0.83 DHODH (0.40) DHODHPDE2AHPGDALDH1A1CASP3
SCHEMBL9070501 0.83 TUBB4A (0.36) DHODHPDE2ATAS1R3TAS1R1TAS1R2
SCHEMBL8752752 0.82 DHODH (0.36) DHODHPDE2AHPGDALDH1A1CASP3
SCHEMBL8752743 0.82 DHODH (0.36) DHODHPDE2AHPGDALDH1A1CASP3
SCHEMBL9113826 0.82 DHODH (0.38) DHODHPDE2AHPGDALDH1A1CASP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0560482-B1 4-Benzoyl isoxazole derivatives and their use as herbicides RHONE POULENC AGRICULTURE (GB) 1997-08-06 EP claimed
EP-0560482-A1 4-Benzoyl isoxazoles derivatives and their use as herbicides RHONE-POULENC AGRICULTURE LTD. (GB) 1993-09-15 EP claimed
US-5859283-A TERTIARY-BUTYL 3-CYCLOALKYL-3-OXOPROPIONATE RHONE-POULENC AGRICULTURE LIMITED (GB) 1999-01-12 US disclosed
US-5747424-A HEATING AN AROMATIC DIKETONE WITH A SALT OF HYDROXYLAMINE IN A SOLVENT RHONE-POULENC AGRICULTURE LTD. (GB) 1998-05-05 US disclosed
US-5656573-A Herbicidal 4-substituted isoxazoles RHONE-POULENC AGRICULTURE LTD. (GB) 1997-08-12 US disclosed
EP-0560482-B1 4-Benzoyl isoxazole derivatives and their use as herbicides RHONE POULENC AGRICULTURE (GB) 1997-08-06 EP disclosed
US-5650533-A Intermediates to herbicidal 4-substituted isoxazoles RHONE-POULENC AGRICULTURE LTD. (GB) 1997-07-22 US disclosed
EP-0560482-A1 4-Benzoyl isoxazoles derivatives and their use as herbicides RHONE-POULENC AGRICULTURE LTD. (GB) 1993-09-15 EP disclosed