Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2112155 | 0.85 | POLB (0.46) | MAPTALDH1A1GAALMNAPOLB | |
| SCHEMBL2112157 | 0.85 | POLB (0.46) | MAPTALDH1A1GAALMNAPOLB | |
| SCHEMBL5516078 | 0.85 | POLB (0.46) | MAPTALDH1A1GAALMNAPOLB | |
| SCHEMBL2112154 | 0.85 | POLB (0.46) | MAPTALDH1A1GAALMNAPOLB | |
| SCHEMBL8428288 | 0.77 | PKM (0.41) | ALDH1A1GAALMNAPOLBSMN1; SMN2 | |
| SCHEMBL7458765 | 0.71 | ALDH1A1 (0.46) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL8314886 | 0.71 | ALDH1A1 (0.46) | MAPTALDH1A1POLBMEN1KMT2A | |
| SCHEMBL4180042 | 0.71 | POLB (0.49) | ALDH1A1GAALMNAPOLBSMN1; SMN2 | |
| SCHEMBL4180046 | 0.71 | POLB (0.49) | ALDH1A1GAALMNAPOLBSMN1; SMN2 | |
| SCHEMBL4180039 | 0.71 | POLB (0.49) | ALDH1A1GAALMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6008347-A | N-substituted 2-azetidinones | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-28 | — | — | US | disclosed |
| US-5412092-A | N-substituted 2-azetidinones | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-05-02 | — | — | US | disclosed |
| EP-0627418-A1 | N-subtituted 2-azetidinones and processes for the production of N-unsubstituted 2-azetidinones therefrom | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-12-07 | — | — | EP | disclosed |