Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26132980 | 0.86 | RAB9A (0.57) | NPC1RAB9ARECQLTDP1SMN1; SMN2 | |
| SCHEMBL10263950 | 0.84 | NPC1 (0.56) | NPC1RAB9ARECQLTDP1SMN1; SMN2 | |
| SCHEMBL310065 | 0.84 | NPC1 (0.56) | NPC1RAB9ARECQLTDP1SMN1; SMN2 | |
| SCHEMBL29905043 | 0.83 | NPC1 (0.79) | NPC1RAB9ARECQLTDP1SMN1; SMN2 | |
| SCHEMBL2057627 | 0.83 | NPC1 (0.79) | NPC1RAB9ARECQLTDP1SMN1; SMN2 | |
| SCHEMBL28436127 | 0.83 | NPC1 (0.54) | NPC1RAB9ARECQLTDP1SMN1; SMN2 | |
| SCHEMBL1141627 | 0.82 | TDP1 (0.60) | NPC1RAB9ARECQLTDP1SMN1; SMN2 | |
| SCHEMBL30072726 | 0.82 | TDP1 (0.60) | NPC1RAB9ARECQLTDP1SMN1; SMN2 | |
| SCHEMBL310951 | 0.82 | KDM4E (0.55) | NPC1RAB9ARECQLTDP1SMN1; SMN2 | |
| SCHEMBL9506168 | 0.82 | NPC1 (0.53) | NPC1RAB9ARECQLTDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1248246-A | 4-aminoethoxyindazole derivatives | AMERICAN HOME PROD (US) | 2000-03-22 | — | — | CN | disclosed |
| EP-0960101-A1 | 4-AMINOETHOXYINDAZOLE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-01 | — | — | EP | disclosed |
| US-5872144-A | DOPAMINERGIC AGENTS USEFUL IN THE TREATMENT OF SCHIZOPHRENIA, TOURETTE'S SYNDROME, DRUG AND ALCOHOL ADDICTION, AND ALSO USEFUL IN THE TREATMENT OF PARKINSON'S DISEASE. | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-02-16 | — | — | US | disclosed |
| WO-1998035942-A1 | 4-AMINOETHOXYINDAZOLE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-08-20 | — | — | WO | disclosed |
| WO-1998035943-A1 | 4-AMINOETHOXYINDAZOLE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-08-20 | — | — | WO | disclosed |