Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 12/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8488106 | 0.92 | AGTR1 (0.41) | AGTR1ABCB11GP6LTB4R2FFAR4 | |
| SCHEMBL8482053 | 0.90 | ALDH1A1 (0.46) | AGTR1ABCB11GP6LTB4R2FFAR4 | |
| SCHEMBL8482866 | 0.89 | AGTR1 (0.44) | AGTR1ABCB11GP6LTB4R2TRPV1 | |
| SCHEMBL8483027 | 0.89 | AGTR1 (0.42) | AGTR1ABCB11GP6LTB4R2FFAR4 | |
| SCHEMBL8488010 | 0.88 | AGTR1 (0.36) | AGTR1ABCB11GP6LTB4R2ALDH1A1 | |
| SCHEMBL8486308 | 0.88 | AGTR1 (0.49) | AGTR1ABCB11GP6LTB4R2ALDH1A1 | |
| SCHEMBL8484301 | 0.87 | AGTR1 (0.44) | AGTR1ABCB11GP6LTB4R2FFAR4 | |
| SCHEMBL8487994 | 0.87 | AGTR1 (0.41) | AGTR1ABCB11GP6LTB4R2FFAR4 | |
| SCHEMBL8485808 | 0.86 | AGTR1 (0.54) | AGTR1ABCB11GP6LTB4R2TRPV1 | |
| SCHEMBL8806218 | 0.85 | AGTR1 (0.61) | AGTR1ABCB11GP6LTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955487-A | TREATING HIGH BLOOD PRESSURE, CARDIAC INSUFFICIENCY, GLAUCOMA | CIBA-GEIGY CORPORATION (US) | 1999-09-21 | — | — | US | disclosed |
| EP-0528762-B1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA GEIGY AG (CH) | 1997-05-07 | — | — | EP | disclosed |
| US-5620998-A | CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-04-15 | — | — | US | disclosed |
| US-5506240-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0528762-A1 | N-acyl-N-heterocyclyl- or naphthyl-alkyl amino acids as angiotensin II antagonists | CIBA-GEIGY AG (CH) | 1993-02-24 | — | — | EP | disclosed |