Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BUB1 | O43683 | 19/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8490579 | 0.92 | BUB1 (0.56) | BUB1 | |
| SCHEMBL8490091 | 0.84 | BUB1 (0.53) | BUB1 | |
| SCHEMBL8581967 | 0.83 | BUB1 (0.48) | BUB1 | |
| SCHEMBL8494310 | 0.83 | BUB1 (0.48) | BUB1 | |
| SCHEMBL8490734 | 0.82 | BUB1 (0.51) | BUB1 | |
| SCHEMBL8494007 | 0.82 | BUB1 (0.51) | BUB1 | |
| SCHEMBL8489551 | 0.82 | GABRA1 (0.54) | BUB1 | |
| SCHEMBL8492453 | 0.81 | ALPL (0.52) | BUB1 | |
| SCHEMBL8496265 | 0.81 | BUB1 (0.79) | BUB1 | |
| SCHEMBL8582722 | 0.81 | BUB1 (0.48) | BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999062899-A1 | TETRAHYDROINDOLONE DERIVATIVES AS GABAAALPHA5 LIGANDS FOR ENHANCING COGNITION | MERCK SHARP & DOHME LIMITED (GB) | 1999-12-09 | — | — | WO | disclosed |