Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 15/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.61 |
| ▸ | PDE4A | P27815 | 6/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354406 | 0.90 | PDE4D (0.76) | PDE4DPDE4BPDE4APDE4CABCB11 | |
| SCHEMBL7379219 | 0.88 | PDE4D (0.79) | PDE4DPDE4BPDE4APDE4CABCB11 | |
| SCHEMBL71596 | 0.80 | PDE4D (0.56) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7341113 | 0.77 | PDE4D (0.84) | PDE4DPDE4BPDE4APDE4CABCB11 | |
| SCHEMBL7336538 | 0.77 | PDE4D (0.84) | PDE4DPDE4BPDE4APDE4CABCB11 | |
| SCHEMBL7336534 | 0.77 | PDE4D (0.84) | PDE4DPDE4BPDE4APDE4CABCB11 | |
| SCHEMBL2889262 | 0.76 | PDE4B (0.74) | PDE4DPDE4BPDE4APDE4CABCB11 | |
| SCHEMBL30084828 | 0.76 | PDE4B (0.74) | PDE4DPDE4BPDE4APDE4CABCB11 | |
| Piclamilast SCHEMBL26573 | 0.76 | PDE4D (1.00) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7335658 | 0.76 | PDE4D (0.79) | PDE4DPDE4BPDE4APDE4CABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935978-A | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group | RHONE-POULENC RORER LIMITED (GB) | 1999-08-10 | — | — | US | disclosed |