SCHEMBL8490397

SCHEMBL8490397

O=c1oc2cc(O)ccc2c(O)c1O

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO1 P15559 3/20 0.69
PDE2A O00408 1/20 0.67
HSD17B3 P37058 3/20 0.65
PKLR P30613 1/20 0.62
NPSR1 Q6W5P4 1/20 0.62
RXFP1 Q9HBX9 1/20 0.62
KDM4E B2RXH2 4/20 0.61
ALDH1A1 P00352 4/20 0.61
ESR1 P03372 4/20 0.61
ESR2 Q92731 4/20 0.61
LMNA P02545 2/20 0.61
MAPT P10636 2/20 0.61
GLA P06280 2/20 0.61
GAA P10253 2/20 0.61
HPGD P15428 2/20 0.61
MAOA P21397 2/20 0.61
KMT2A Q03164 2/20 0.61
MEN1 O00255 1/20 0.61
MGAM O43451 1/20 0.61
NR1I2 O75469 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Iodomethane SCHEMBL8494114 0.94 HSD17B3 (0.64) NQO1PDE2AHSD17B3PKLRNPSR1
SCHEMBL8493787 0.84 PDE2A (0.56) NQO1PDE2AHSD17B3PKLRKDM4E
SCHEMBL31312649 0.83 HSD17B3 (0.80) NQO1PDE2AHSD17B3PKLRNPSR1
SCHEMBL29738721 0.83 NQO1 (0.63) NQO1PDE2AHSD17B3PKLRNPSR1
SCHEMBL3457273 0.83 NQO1 (0.63) NQO1PDE2AHSD17B3PKLRNPSR1
Hydrochloric Acid SCHEMBL14743958 0.82 NQO1 (0.61) NQO1PDE2AHSD17B3PKLRNPSR1
SCHEMBL803408 0.80 PDE2A (1.00) NQO1PDE2AHSD17B3PKLRNPSR1
SCHEMBL29401099 0.80 PDE2A (1.00) NQO1PDE2AHSD17B3PKLRNPSR1
SCHEMBL16663940 0.80 PDE2A (0.85) NQO1PDE2AHSD17B3PKLRNPSR1
SCHEMBL29368885 0.80 PDE2A (1.00) NQO1PDE2AHSD17B3PKLRNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-8092086-A None JP disclosed
EP-0598117-B1 BENZOPYRAN DERIVATIVE AND ANTIALLERGIC AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT DAINIPPON INK & CHEMICALS (JP) 1999-06-30 EP disclosed
JP-H0892086-A MEDICINE FOR ATOPIC DERMATITIS DAINIPPON INK & CHEM INC 1996-04-09 JP disclosed
US-5428059-A Benzopyran derivatives and an anti-allergic agent possessing the same as the active ingredient DAINIPPON INK & CHEMICALS, INC. (JP) 1995-06-27 US disclosed
EP-0598117-A1 BENZOPYRAN DERIVATIVE AND ANTIALLERGIC AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT DAINIPPON INK AND CHEMICALS, INC. (JP) 1994-05-25 EP disclosed