Indole

Indole

SCHEMBL849126

OCC(O)CO.c1ccc2[nH]ccc2c1

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 7/20 0.65
TRPA1 O75762 1/20 0.65
CA1 P00915 1/20 0.65
CA2 P00918 1/20 0.65
ITGB2 P05107 1/20 0.65
ICAM1 P05362 1/20 0.65
ITGAL P20701 1/20 0.65
CA4 P22748 1/20 0.65
CA6 P23280 1/20 0.65
ADK P55263 1/20 0.65
NPC1 O15118 1/20 0.39
TYR P14679 1/20 0.38
USP2 O75604 1/20 0.38
GAA P10253 1/20 0.38
ALOX15 P16050 1/20 0.38
RAD51 Q06609 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
CTNNB1 P35222 1/20 0.38
WNT3A P56704 1/20 0.38
SLC6A2 P23975 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Indole SCHEMBL31338620 1.00 AHR (0.65) AHRTRPA1CA1CA2ITGB2
Indole SCHEMBL2928009 0.92 TRPA1 (0.55) AHRTRPA1CA1CA2ITGB2
Indole SCHEMBL541659 0.92 TRPA1 (0.55) AHRTRPA1CA1CA2ITGB2
Indole SCHEMBL27856435 0.87 TRPA1 (0.63) AHRTRPA1CA1CA2ITGB2
Indole SCHEMBL11219857 0.84 AHR (0.77) AHRTRPA1CA1CA2ITGB2
Indole SCHEMBL399069 0.82 AHR (0.74) AHRTRPA1CA1CA2ITGB2
Indole SCHEMBL6386255 0.81 AHR (0.90) AHRTRPA1CA1CA2ITGB2
Indole SCHEMBL30463845 0.81
Indole SCHEMBL1160186 0.81 AHR (1.00) AHRTRPA1CA1CA2ITGB2
Indole SCHEMBL698 0.81

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 218 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040047892-A1 Filler composition for soft tissue augmentation and reconstructive surgery DESROSIERS ERIC ANDRE (CA) 2004-03-11 US claimed
EP-1333869-A2 FILLER COMPOSITION FOR SOFT TISSUE AUGMENTATION Bio Syntech Canada Inc. (CA) 2003-08-13 EP claimed
EP-1003567-B1 TEMPERATURE-CONTROLLED pH-DEPENDANT FORMATION OF IONIC POLYSACCHARIDE GELS BIOSYNTECH CANADA INC (CA) 2003-08-06 EP claimed
WO-2002040072-A2 FILLER COMPOSITION FOR SOFT TISSUE AUGMENTATION AND RECONSTRUCTIVE SURGERY BIO SYNTECH CANADA INC. (CA) 2002-05-23 WO claimed
US-6344488-B1 Temperature-controlled pH-dependent formation of ionic polysaccharide gels BIO SYNTECH 2002-02-05 US claimed
EP-1003567-A1 TEMPERATURE-CONTROLLED pH-DEPENDANT FORMATION OF IONIC POLYSACCHARIDE GELS Bio-Syntech Ltd. (CA) 2000-05-31 EP claimed
WO-1999007416-A1 TEMPERATURE-CONTROLLED pH-DEPENDANT FORMATION OF IONIC POLYSACCHARIDE GELS BIO-SYNTECH LTD. (CA) 1999-02-18 WO claimed
US-20230332126-A1 Botulinum Neurotoxin Proteins and Methods to Engineer and Generate Same UNIV CALIFORNIA (US) 2023-10-19 US disclosed
EP-3447134-B1 INCREASED FUNGAL RESISTANCE IN CROP PLANTS KWS SAAT SE & CO KGAA (DE) 2023-10-11 EP disclosed
EP-4204437-A1 BOTULINUM NEUROTOXIN PROTEINS AND METHODS TO ENGINEER AND GENERATE SAME The Regents of the University of California (US) 2023-07-05 EP disclosed
US-20230021982-A1 INCREASED FUNGAL RESISTANCE IN PLANTS VIA MODULATION OF A WALL-ASSOCIATED KINASE OR BENZOXAZINOIDS KWS SAAT SE & Co. KGaA (DE) 2023-01-26 US disclosed
CN-108486143-B Fungus RNA interference vector pBHt2-CHSA Intron, construction method and application 河南农业大学 2021-09-03 CN disclosed
CN-105431539-B Novel organic acid pathway 乐斯福公司 2021-05-25 CN disclosed
WO-1998003661-A9 ANTIMICROBIAL AGENTS, DIAGNOSTIC REAGENTS, AND VACCINES BASED ON UNIQUE APICOMPLEXAN PARASITE COMPONENTS 1998-05-28 WO disclosed
WO-1998013496-A1 CHAPERONE FRAGMENTS MEDICAL RESEARCH COUNCIL (GB) 1998-04-02 WO disclosed
WO-1998003661-A2 ANTIMICROBIAL AGENTS, DIAGNOSTIC REAGENTS, AND VACCINES BASED ON UNIQUE APICOMPLEXAN PARASITE COMPONENTS ARCH DEVELOPMENT CORPORATION (US) 1998-01-29 WO disclosed
US-5187071-A Method for the selective control of weeds, pests, and microbes FISCHER RANDY S (US) 1993-02-16 US disclosed
US-5021076-A Inoculating roots of leguminous plants; symbiosis THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1991-06-04 US disclosed
US-4816405-A Vectors for transformation by ascomycetes THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1989-03-28 US disclosed
EP-0191221-A1 Vectors for transformation of ascomycetes THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1986-08-20 EP disclosed