Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | IDH2 | P48735 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12984259 | 0.88 | DHODH (0.53) | SYKLMNATAS2R14NPC1RAB9A | |
| SCHEMBL30721208 | 0.88 | DHODH (0.53) | SYKLMNATAS2R14NPC1RAB9A | |
| SCHEMBL29110319 | 0.86 | MAPT (0.49) | SYKLMNATAS2R14NPC1RAB9A | |
| SCHEMBL22093021 | 0.86 | MAPK8 (0.51) | SYKLMNATAS2R14 | |
| SCHEMBL14575828 | 0.85 | NPC1 (0.43) | SYKLMNATAS2R14NPC1RAB9A | |
| SCHEMBL29417547 | 0.85 | NPC1 (0.43) | SYKLMNATAS2R14NPC1RAB9A | |
| SCHEMBL12983920 | 0.81 | TUBB4A (0.41) | SYKLMNATAS2R14NPC1RAB9A | |
| SCHEMBL14604426 | 0.80 | TRPV1 (0.48) | SYKTAS2R14NPC1RAB9AGSK3A | |
| SCHEMBL846982 | 0.79 | MAPT (0.44) | LMNANPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL29305792 | 0.79 | SYK (0.44) | SYKTAS2R14NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2694480-B1 | ADAMANTYL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2015-03-04 | — | — | EP | disclosed |
| EP-2694480-A1 | ADAMANTYL COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-02-12 | — | — | EP | disclosed |
| US-8471027-B2 | Adamantyl compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-8471027-B2 | Adamantyl compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-8471027-B2 | Adamantyl compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120258982-A1 | ADAMANTYL COMPOUNDS | CHEUNG ADRIAN WAI-HING (US) | 2012-10-11 | — | — | US | disclosed |
| US-20120258982-A1 | ADAMANTYL COMPOUNDS | CHEUNG ADRIAN WAI-HING (US) | 2012-10-11 | — | — | US | disclosed |
| WO-2012136684-A1 | ADAMANTYL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-10-11 | — | — | WO | disclosed |
| US-20120258982-A1 | ADAMANTYL COMPOUNDS | CHEUNG ADRIAN WAI-HING (US) | 2012-10-11 | — | — | US | disclosed |
| US-8163906-B2 | Dihydroquinone and dihydronaphthridine inhibitors of JNK | ROCHE PALO ALTO, LLC (US) | 2012-04-24 | — | — | US | disclosed |
| EP-2148862-B1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | HOFFMANN LA ROCHE (CH) | 2012-03-28 | — | — | EP | disclosed |
| EP-2148862-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. Hoffmann-Roche AG (CH) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008138920-A1 | DIHYDROQUINONE AND DIHYDRONAPHTHRIDINE INHIBITORS OF JNK | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |
| US-20080287458-A1 | Dihydroquinone and dihydronaphthridine inhibitors of JNK | ROCHE PALO ALTO LLC | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258982-A1 | ADAMANTYL COMPOUNDS | MAP3K1, MAP3K6, MAPKAPK2 | SYK 1290/4885LMNA 2750/4885TAS2R14 4396/4885 |
| US-20080287458-A1 | Dihydroquinone and dihydronaphthridine inhibitors of JNK | MAPK9, MAPK10, MAPK1 | SYK 598/4885LMNA 3935/4885TAS2R14 3238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.