Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 8/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | ADAMTS7 | Q9UKP4 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 4/20 | 0.35 |
| ▸ | MMP9 | P14780 | 2/20 | 0.35 |
| ▸ | MMP8 | P22894 | 2/20 | 0.35 |
| ▸ | MMP13 | P45452 | 2/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8496434 | 0.88 | ADAMTS7 (0.36) | ADAMTS5ADAM17ADAMTS7MMP2MMP9 | |
| SCHEMBL8491375 | 0.87 | ADAMTS5 (0.40) | ADAMTS5HSD11B1MMP2MMP13GRM2 | |
| SCHEMBL8496566 | 0.85 | GRM2 (0.41) | ADAMTS5MMP2MMP13GRM2GRM3 | |
| SCHEMBL8495956 | 0.84 | GRM2 (0.42) | ADAMTS5GRM2GRM3 | |
| SCHEMBL8496048 | 0.84 | ADAMTS5 (0.39) | ADAMTS5ADAM17ADAMTS7MMP2MMP9 | |
| SCHEMBL8490712 | 0.83 | FFAR4 (0.40) | ADAMTS5ADAMTS7 | |
| SCHEMBL8497135 | 0.82 | ADAMTS5 (0.40) | ADAMTS5ADAM17ADAMTS7MMP2MMP13 | |
| SCHEMBL8491656 | 0.82 | ADAMTS5 (0.40) | ADAMTS5ADAM17ADAMTS7MMP2MMP13 | |
| SCHEMBL8490895 | 0.82 | ADAMTS5 (0.40) | ADAMTS5ADAM17ADAMTS7MMP2MMP13 | |
| SCHEMBL8491658 | 0.82 | ADAMTS5 (0.40) | ADAMTS5ADAM17ADAMTS7MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-B1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1999-12-08 | — | — | EP | disclosed |
| US-5717109-A | CARBOXYCYCLOPROPYL GLYCINE DERIVATIVES; USEFUL FOR TREATMENT OF ACUTE OR CHRONIC NEURODEGENERATIVE CONDITIONS, AND AS ANTIPSYCHOTIC, ANTICONVULSANT, ANALGESIC, ANXIOLYTIC, ANTIDEPRESSANT AND ANTI-EMETIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |