SCHEMBL8495462

SCHEMBL8495462

O=CN(CCO)OCc1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR6 P51684 1/20 0.38
PAX8 Q06710 1/20 0.38
ALDH1A1 P00352 3/20 0.38
TSHR P16473 2/20 0.38
HCAR2 Q8TDS4 1/20 0.38
TDP1 Q9NUW8 2/20 0.37
KMT2A Q03164 2/20 0.37
MAPK1 P28482 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
SLC6A2 P23975 1/20 0.37
SLC6A3 Q01959 1/20 0.37
SLC1A3 P43003 2/20 0.36
SLC1A2 P43004 2/20 0.36
SLC1A1 P43005 2/20 0.36
MEN1 O00255 1/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
LMNA P02545 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7305614 0.90 LTA4H (0.41) CCR6PAX8ALDH1A1TSHRHCAR2
SCHEMBL667448 0.89 CCR6 (0.42) CCR6PAX8ALDH1A1TSHRHCAR2
SCHEMBL7739753 0.87 CCR6 (0.41) CCR6PAX8ALDH1A1L3MBTL1LTA4H
SCHEMBL8989023 0.87 CCR6 (0.41) CCR6PAX8ALDH1A1L3MBTL1LTA4H
SCHEMBL8592588 0.86 ALDH1A1 (0.40) ALDH1A1TSHRHCAR2TDP1KMT2A
SCHEMBL6949217 0.84 TAAR1 (0.42) TSHRTDP1KMT2AMEN1IDO1
SCHEMBL6951407 0.83 HTT (0.44) CCR6PAX8ALDH1A1HCAR2MAPK1
SCHEMBL10473639 0.83 CARM1 (0.41) ALDH1A1TSHRKMT2ASLC1A3SLC1A2
SCHEMBL1415899 0.83 TSHR (0.38) ALDH1A1TSHRHCAR2TDP1KMT2A
SCHEMBL7372303 0.83 TSHR (0.42) TSHRL3MBTL1CYP2C9CYP2C19LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-61246196-A None JP disclosed
US-5914313-A ANTIBIOTICS MERCK & CO., INC. (US) 1999-06-22 US disclosed
EP-0389437-B1 Luciferin derivatives NIPPON ZOKI PHARMACEUTICAL CO (JP) 1995-05-24 EP disclosed
WO-1994009033-A1 AN IMPROVED PROCESS FOR CYCLOHEXAPEPTIDYL BISAMINE COMPOUNDS MERCK & CO., INC. (US) 1994-04-28 WO disclosed
US-5166135-A Administering cyclohexapeptide antibiotic; AIDS MERCK & COMPANY, INC. (US) 1992-11-24 US disclosed
US-5128069-A Luciferin derivatives NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) 1992-07-07 US disclosed
EP-0389437-A1 Luciferin derivatives NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) 1990-09-26 EP disclosed
JP-S61246196-A 5'-O-ACYL-5-FLUOROURIDINE AND PRODUCTION THEREOF FUJI KAGAKU KOGYO KK 1986-11-01 JP disclosed
US-4092324-A ANTIARTERIOSCLEROSIS AGENTS SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1978-05-30 US disclosed
US-4008265-A ANTIARTERIOSCLEROSIS SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1977-02-15 US disclosed