Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.50 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.50 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.50 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL427538 | 0.83 | LTA4H (0.59) | LTA4HEPHX2FFAR1 | |
| SCHEMBL1406143 | 0.82 | SIGMAR1 (0.64) | GAAATMSIGMAR1 | |
| SCHEMBL8499156 | 0.82 | LTA4H (0.82) | LTA4HEPHX2OPRM1OPRD1OPRK1 | |
| SCHEMBL9081140 | 0.82 | LTA4H (0.82) | LTA4HEPHX2OPRM1OPRD1OPRK1 | |
| SCHEMBL1108563 | 0.81 | TAAR1 (0.67) | LTA4HEPHX2PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL13973066 | 0.81 | KDM4E (0.59) | LTA4HEPHX2OPRM1OPRD1OPRK1 | |
| SCHEMBL13886610 | 0.81 | BCHE (0.74) | BCHEMEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL27879511 | 0.81 | LTA4H (0.57) | LTA4HEPHX2FFAR1 | |
| Hydrochloric Acid SCHEMBL3739565 | 0.81 | GAA (0.65) | GAAMEN1KMT2AATMSIGMAR1 | |
| SCHEMBL10098558 | 0.80 | LTA4H (0.68) | LTA4HEPHX2OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928231-B2 | Thienopyrazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2011-04-19 | — | — | US | disclosed |
| US-20100056514-A1 | THIENOPYRAZOLES | AVENTIS PHARMACEUTICALS INC. (US) | 2010-03-04 | — | — | US | disclosed |
| US-7518000-B2 | Thienopyrazoles | AVENTIS PHARMACEUTICALS, INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-20070254937-A1 | Thienopyrazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2007-11-01 | — | — | US | disclosed |
| EP-0677039-B1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LAB (US) | 1999-03-10 | — | — | EP | disclosed |
| US-5783593-A | FUNGICIDE; ANTICHOLESTEROL AGENT | ABBOTT LABORATORIES (US) | 1998-07-21 | — | — | US | disclosed |
| WO-1996034850-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |
| WO-1995012572-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1995-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056514-A1 | THIENOPYRAZOLES | ITK, IL2, TYK2 | LTA4H 1258/4885EPHX2 2219/4885OPRM1 4365/4885 |
| US-20070254937-A1 | Thienopyrazoles | ITK, IL2, JAK2 | LTA4H 1170/4885EPHX2 1819/4885OPRM1 4130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.