Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8471717 | 0.85 | EDNRA (0.80) | EDNRAEDNRB | |
| SCHEMBL6696366 | 0.84 | EDNRA (0.66) | EDNRAEDNRB | |
| SCHEMBL6703895 | 0.82 | EDNRA (0.71) | EDNRAEDNRB | |
| SCHEMBL7557151 | 0.80 | EDNRA (0.64) | EDNRAEDNRB | |
| SCHEMBL26552022 | 0.78 | EDNRA (0.76) | EDNRAEDNRB | |
| SCHEMBL7552444 | 0.78 | ALDH1A1 (0.48) | EDNRAEDNRB | |
| SCHEMBL6963011 | 0.77 | EDNRA (0.68) | EDNRAEDNRB | |
| SCHEMBL7383296 | 0.77 | EDNRB (0.90) | EDNRAEDNRB | |
| Edonentan SCHEMBL29742313 | 0.77 | EDNRA (1.00) | EDNRAEDNRB | |
| Edonentan SCHEMBL1651069 | 0.77 | EDNRA (1.00) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916907-A | Method for preventing or treating low renin hypertension by administering an endothelin antagonist | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-06-29 | — | — | US | claimed |
| US-5916907-A | Method for preventing or treating low renin hypertension by administering an endothelin antagonist | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-06-29 | — | — | US | disclosed |
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | disclosed |