Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.74 |
| ▸ | BCHE | P06276 | 4/20 | 0.73 |
| ▸ | LTA4H | P09960 | 1/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.66 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8493877 | 0.95 | BCHE (0.72) | SIGMAR1BCHELTA4HEPHX2MAOA | |
| SCHEMBL9081140 | 0.88 | LTA4H (0.82) | BCHELTA4HEPHX2OPRM1OPRD1 | |
| SCHEMBL8499156 | 0.88 | LTA4H (0.82) | BCHELTA4HEPHX2OPRM1OPRD1 | |
| SCHEMBL9154589 | 0.86 | LTA4H (0.79) | BCHELTA4HEPHX2OPRM1OPRD1 | |
| SCHEMBL8814963 | 0.86 | LTA4H (0.78) | SIGMAR1BCHELTA4HEPHX2OPRM1 | |
| SCHEMBL6014422 | 0.86 | SIGMAR1 (1.00) | SIGMAR1BCHEMAOACHRM2 | |
| SCHEMBL6014369 | 0.84 | SIGMAR1 (1.00) | SIGMAR1BCHEMAOACHRM2 | |
| SCHEMBL7756958 | 0.84 | SIGMAR1 (1.00) | SIGMAR1BCHEMAOACHRM2 | |
| SCHEMBL6014543 | 0.84 | SIGMAR1 (1.00) | SIGMAR1BCHEMAOACHRM2 | |
| SCHEMBL8097260 | 0.84 | SIGMAR1 (1.00) | SIGMAR1BCHEMAOACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0677039-B1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LAB (US) | 1999-03-10 | — | — | EP | disclosed |
| US-5783593-A | FUNGICIDE; ANTICHOLESTEROL AGENT | ABBOTT LABORATORIES (US) | 1998-07-21 | — | — | US | disclosed |
| US-5631401-A | Inhibitors of protein farnesyltransferase and squalene synthase | ABBOTT LABORATORIES (US) | 1997-05-20 | — | — | US | disclosed |
| WO-1996034850-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |
| EP-0677039-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | Abbott Laboratories (US) | 1995-10-18 | — | — | EP | disclosed |
| WO-1995021815-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND SQUALENE SYNTHASE | ABBOTT LABORATORIES (US) | 1995-08-17 | — | — | WO | disclosed |
| WO-1995012572-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1995-05-11 | — | — | WO | disclosed |