Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 14/20 | 0.48 |
| ▸ | MMP13 | P45452 | 14/20 | 0.48 |
| ▸ | MMP1 | P03956 | 13/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | MMP7 | P09237 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8498354 | 0.80 | MMP9 (0.50) | MMP9MMP13MMP1ADAM17ALDH1A1 | |
| SCHEMBL8527273 | 0.80 | MMP9 (0.50) | MMP9MMP13MMP1ADAM17ALDH1A1 | |
| SCHEMBL3067553 | 0.79 | HPGD (0.43) | SMN1; SMN2ALDH1A1CA12CA1CA2 | |
| SCHEMBL2105715 | 0.77 | APP (0.40) | MMP9MMP13MMP1ADAM17ALDH1A1 | |
| SCHEMBL8500443 | 0.77 | MMP9 (0.43) | MMP9MMP13MMP1ADAM17APP | |
| SCHEMBL8502526 | 0.76 | MMP1 (0.46) | MMP9MMP13MMP1ADAM17SMN1; SMN2 | |
| SCHEMBL8498342 | 0.75 | MMP1 (0.39) | MMP9MMP13MMP1TSHRRECQL | |
| SCHEMBL2105237 | 0.75 | APP (0.39) | MMP9MMP13MMP1ADAM17ALDH1A1 | |
| SCHEMBL8499613 | 0.74 | MMP9 (0.48) | MMP9MMP13MMP1ADAM17ALDH1A1 | |
| SCHEMBL8501596 | 0.74 | MMP9 (0.44) | MMP9MMP13MMP1ADAM17PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927161-A1 | SUBSTITUTED CYCLIC AMINE METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998008815-A1 | SUBSTITUTED CYCLIC AMINE METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |