Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 6/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.44 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8499475 | 1.00 | S1PR1 (0.49) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL8496364 | 0.97 | S1PR1 (0.48) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL8498340 | 0.96 | S1PR1 (0.47) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL8499108 | 0.94 | S1PR1 (0.53) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL8499845 | 0.94 | ALDH1A1 (0.46) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL8499033 | 0.94 | S1PR1 (0.53) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL8499547 | 0.93 | S1PR1 (0.51) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL8499530 | 0.91 | TNNC1 (0.45) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL8499400 | 0.91 | TNNC1 (0.45) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 | |
| SCHEMBL7624773 | 0.90 | S1PR1 (0.51) | S1PR1S1PR4S1PR3S1PR5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952316-A | FOR TREATING AUTOIMMUNE DISEASES, E.G., RHEUMATIOD ARTHRITIS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1999-09-14 | — | — | US | disclosed |
| EP-0627406-B1 | 2-AMINO-1,3-PROPANEDIOL COMPOUND AND IMMUNOSUPPRESSANT | YOSHITOMI PHARMACEUTICAL (JP) | 1998-10-28 | — | — | EP | disclosed |
| US-5719176-A | 2-amino-1,3-propanediol compound and immunosuppressant | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-02-17 | — | — | US | disclosed |
| US-5604229-A | 2-amino-1,3-propanediol compound and immunosuppressant | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-02-18 | — | — | US | disclosed |
| EP-0627406-A1 | 2-AMINO-1,3-PROPANEDIOL COMPOUND AND IMMUNOSUPPRESSANT | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-12-07 | — | — | EP | disclosed |