Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.50 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8505189 | 0.89 | POLB (0.54) | POLBKDM4EDRD4SIGMAR1ABCB1 | |
| SCHEMBL8500338 | 0.86 | POLB (0.60) | POLBKDM4EDRD4SIGMAR1ABCB1 | |
| SCHEMBL8501315 | 0.83 | SIGMAR1 (0.68) | POLBKDM4ESIGMAR1ABCB1ABCC1 | |
| SCHEMBL8504854 | 0.81 | TDP1 (0.54) | POLBKDM4EDRD4SIGMAR1MEN1 | |
| SCHEMBL8498783 | 0.80 | KDM4E (0.66) | POLBKDM4EABCB1ABCC1MEN1 | |
| SCHEMBL8490065 | 0.80 | KDM4E (0.77) | POLBKDM4EABCB1ABCC1MEN1 | |
| SCHEMBL8507999 | 0.78 | POLB (0.54) | POLBKDM4EDRD4SIGMAR1ABCB1 | |
| SCHEMBL8501110 | 0.77 | KDM4E (0.62) | POLBKDM4EABCB1ABCC1MEN1 | |
| SCHEMBL8504726 | 0.77 | DHCR7 (0.70) | POLBKDM4ESIGMAR1ABCB1MEN1 | |
| SCHEMBL8506486 | 0.76 | DHCR7 (0.53) | POLBKDM4ESIGMAR1ABCB1ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999024022-A2 | ISOQUINOLINE DERIVATIVES FOR TREATING DISORDERS ASSOCIATED WITH 5HT7 RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-20 | — | — | WO | disclosed |