SCHEMBL8499862

SCHEMBL8499862

COc1cc(C)c(C(=O)c2c(Cl)cccc2Cl)cc1OC[Si](C)(C)C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RORC P51449 2/20 0.40
CES2 O00748 1/20 0.39
CES1 P23141 1/20 0.39
KDM4E B2RXH2 2/20 0.39
ALDH1A1 P00352 2/20 0.39
GAA P10253 2/20 0.39
HTT P42858 1/20 0.39
LMNA P02545 1/20 0.39
CSF1R P07333 1/20 0.39
PTGS2 P35354 3/20 0.38
RAB9A P51151 2/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
MAPT P10636 1/20 0.37
TSHR P16473 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
HSD17B10 Q99714 1/20 0.37
DOT1L Q8TEK3 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
NPC1 O15118 1/20 0.36
HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6150594 0.87 CES2 (0.48) RORCCES2CES1KDM4EALDH1A1
SCHEMBL8463397 0.86 TSHR (0.45) RORCCES2CES1GAALMNA
SCHEMBL8463650 0.84 PDE4B (0.43) RORCCES2CES1KDM4EGAA
SCHEMBL8466614 0.83 PDE4B (0.44) RORCCES2CES1KDM4EALDH1A1
SCHEMBL8463389 0.83 CYP2B6 (0.47) RORCCES2CES1KDM4EALDH1A1
SCHEMBL8466199 0.83 PDE4B (0.45) RORCCES2CES1GAARAB9A
SCHEMBL8464014 0.82 SMPD1 (0.46) GAAHTTLMNARAB9AL3MBTL1
SCHEMBL6307594 0.82 CES2 (0.46) RORCCES2CES1KDM4EALDH1A1
SCHEMBL8467299 0.81 HTT (0.41) RORCCES2CES1KDM4EALDH1A1
SCHEMBL8466704 0.81 SMPD1 (0.47) LMNAL3MBTL1MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0727141-A2 Fungicidal methods, compounds and compositions containing benzophenones American Cyanamid Company (US) 1996-08-21 EP claimed
US-5866722-A Fungicidal methods compounds and compositions containing benzophenones AMERICAN CYANAMID COMPANY (US) 1999-02-02 US disclosed
US-5773663-A FOR CONTROL OF PHYTOPATHOGENIC FUNGI IN CROPS AMERICAN CYANAMID COMPANY (US) 1998-06-30 US disclosed
US-5679866-A CONTROLLING POWDERY MELDEW DISEASES AMERICAN CYANAMID COMPANY (US) 1997-10-21 US disclosed
EP-0727141-A2 Fungicidal methods, compounds and compositions containing benzophenones American Cyanamid Company (US) 1996-08-21 EP disclosed